Evidence map›Paper›PMID 31641817›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2020

Pharmacokinetics and anti-inflammatory effect of naproxen in rats with acute and subacute spinal cord injury.

Arianna Rodríguez-Cal Y Mayor, Gilberto Castañeda-Hernández, Liliana Favari, Angelina Martinez-Cruz, Gabriel Guízar-Sahagún, Leticia Cruz-Antonio

Abstract read
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Arianna Rodríguez-Cal Y MayorDepartament of Pharmacology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico.ORCID http://orcid.org/0000-0002-4619-2701
Gilberto Castañeda-HernándezDepartament of Pharmacology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico.ORCID http://orcid.org/0000-0001-9149-885X
Liliana FavariDepartament of Pharmacology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico.ORCID http://orcid.org/0000-0003-4414-966X
Angelina Martinez-CruzDepartment of Experimental Surgery, Proyecto Camina A.C., Mexico City, Mexico.ORCID http://orcid.org/0000-0002-1216-3427
Gabriel Guízar-SahagúnDepartment of Experimental Surgery, Proyecto Camina A.C., Mexico City, Mexico. guizarg@gmail.com.ORCID http://orcid.org/0000-0002-2722-5758
Leticia Cruz-AntonioDepartament of Pharmacy, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, Mexico City, Mexico.ORCID http://orcid.org/0000-0001-8812-9711
Instituto Politécnico Nacional · MXGoodyear (United Kingdom) · GBHospital General de México · MXUniversidad Nacional Autónoma de México · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous reports have warned about the influence of spinal cord injury (SCI) on the pharmacokinetics of various drugs. However, the role of SCI in the efficacy and safety of pharmacotherapy remains unknown. Thereby, our aim was to explore the role of SCI on pharmacokinetics and anti-inflammatory effect of naproxen in response to a local inflammatory challenge. Rats received a severe contusive SCI at T9 or sham injury. Pharmacokinetics of a single intravenous dose of naproxen (10 mg kg

Indexed as

AnimalsAnti-Inflammatory Agents, Non-SteroidalFemaleInflammation MediatorsNaproxenRandom AllocationRatsRats, Sprague-DawleySpinal Cord InjuriesThoracic VertebraeTreatment OutcomeAnti-Inflammatory Agents, Non-SteroidalInflammation MediatorsNaproxenBioavailabilityCarrageenanNeurological statusPeripheral inflammationPharmacodynamics

Identifiers

PMID31641817
OpenAlexW2981896145

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.