ArticleThe journal of nutrition, health & aging2019
Allostatic Load as a Biological Substrate to Intrinsic Capacity: A Secondary Analysis of CRELES.
Article in The journal of nutrition, health & aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The assessment and detection rate of intrinsic capacity deficits among older adults: a systematic review and meta-analysis.BMC geriatrics · 2024Pooled it
- A systematic review of the measurement properties of aspects of psychological capacity in older adults.Age and ageing · 2023Pooled it
- A systematic review of multidomain and lifestyle interventions to support the intrinsic capacity of the older population.Frontiers in medicine · 2022Pooled it
- Article
- Low intrinsic capacity is associated with risk of developing mild cognitive impairment in the English Longitudinal Study of Ageing (ELSA).GeroScience · 2026Article
- Association between the cardiometabolic index and intrinsic capacity and its domains in older adults: a study based on CHARLS data.BMC geriatrics · 2026Article
- Intrinsic capacity trajectory and hip fracture risk in Chinese middle-aged and older adults: a 10-year retrospective cohort study.Scientific reports · 2026Article
- Intrinsic capacity and risk of hip fracture in community-dwelling elderly people in China: A 4-year longitudinal cohort study.Aging clinical and experimental research · 2026Article
- An umbrella review of psychological capacity and mental health trajectories across the life course.Nature. Mental health · 2026Article
- Heterogeneous trajectories of intrinsic capacity and their predictors: a Bayesian network analysis of a longitudinal cohort in Chinese nursing homes.Frontiers in public health · 2026Article
- Article
- Abnormal Blood Biomarkers and Cumulative Disability Burden in Middle-Aged and Older Adults: Evidence from Two Nationally Representative Surveys in the United States and China.Journal of cardiovascular development and disease · 2025Article
- Intrinsic Capacity Predictors of Dementia and Mortality in the Sydney Memory and Ageing Study.International journal of geriatric psychiatry · 2025Article
- Intrinsic capacity trajectories and cardiovascular disease incidence among Chinese older adults: a population-based prospective cohort study.BMC geriatrics · 2025Article
- Developmental Trajectories of Intrinsic Capacity Among Older Adults: Results from the China Longitudinal Study of Aging.Healthcare (Basel, Switzerland) · 2025Article
- Protocol for an aged cohort study to create a single indicator that expresses the trajectory of intrinsic capacity over the years and its relation to functional abilities.Frontiers in aging · 2025Article
- Intrinsic capacity, functional and psychosocial aspects of older adults participating in a multicomponent physical exercise program.Frontiers in aging · 2025Article
- Determinants of intrinsic capacity among older adults in low- and middle-income countries: A scoping review.Belitung nursing journal · 2025Review
- Intrinsic capacity transitions predict overall and cause-specific mortality, incident disability, and healthcare utilization.The journal of nutrition, health & aging · 2024Article
- A latent profile analysis of rest-activity behavior patterns among community-dwelling older adults and its relationship with intrinsic capacity.Scientific reports · 2024Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesIntrinsic capacity (IC) is one of the latest views of positive aging. In its current status lacks a biological substrate amenable to be intervened. The aim of this study was to determine the association of allostatic load (AL) with IC.
designWe present a cross-sectional analysis of the Costa Rican Longevity and Healthy Aging Study.
settingThis report is from a representative sample of Costa Rican older adults; one of the countries that integrate the Central America region.
participants2,827, 60-year or older community-dwelling individuals.
methodsAn IC index was gathered and validated, including different domains: cognitive, psychological, sensory, vitality and locomotion. AL was integrated with: blood pressure, abdominal obesity, body mass index, HDL-cholesterol, glycosylated hemoglobin, DHEAS, cortisol, epinephrine and norepinephrine. AL was grouped in three categories according to the number of abnormal biomarkers (0-1, 2-3 and ≥4). Chronic diseases, socioeconomic level, sex and age were the adjusting variables. Ordinal logistic regression models were estimated in order to test the strength of the association.
resultsFrom a total sample of 1,888 individuals, 51% (n=962) were women, 36.4% were in the 60-69 age category. The mean score of the IC index was of 6.6 (±2.2). Odds ratio (OR) of the adjusted models were significant for the group of those with 2-3 abnormal biomarkers of AL (OR 0.67, p=0.007) and also for those with ≥4 (OR 0.56, p=0.002), when compared to the reference group of AL (0-1 abnormal biomarkers). CONCLUSIONS AND IMPLICATIONS: AL showed an incremental association with IC, even when adjusted for factors such as socioeconomic status and chronic diseases. Targeting therapeutically AL could potentially improve IC in older adults and therefore decreasing the progression to disability or to overt dependency.
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