Evidence map›Paper›PMID 31641668›Full record

ArticleBioMed research international2019

Polycystin-1 Inhibits Cell Proliferation through Phosphatase PP2A/B56

Yan Tang, JungWoo Yang, Wang Zheng, Jingfeng Tang, Xing-Zhen Chen, Jianzheng Yang, Zuocheng Wang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Yan TangDepartment of Oncology and Haematology, The Second Hospital, Jilin University, Changchun 130041, China.ORCID https://orcid.org/0000-0003-4036-9788
JungWoo YangMembrane Protein Disease Research Group, Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton T6G 2H7, Canada.
Wang ZhengMembrane Protein Disease Research Group, Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton T6G 2H7, Canada.
Jingfeng TangNational "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan 430086, China.
Xing-Zhen ChenMembrane Protein Disease Research Group, Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton T6G 2H7, Canada.ORCID https://orcid.org/0000-0003-4464-0598
Jianzheng YangDepartment of Radiotherapy, The Second Hospital, Jilin University, Changchun 130041, China.ORCID https://orcid.org/0000-0001-5011-9083
Zuocheng WangMembrane Protein Disease Research Group, Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton T6G 2H7, Canada.ORCID https://orcid.org/0000-0002-7369-1258
University of Alberta · CAHubei University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is associated with a number of cellular defects such as hyperproliferation, apoptosis, and dedifferentiation. Mutations in polycystin-1 (PC1) account for ∼85% of ADPKD. Here, we showed that wild-type (WT) or mutant PC1 composed of the last five transmembrane (TM) domains and the C-terminus (termed PC1-5TMC) inhibits cell proliferation and protein translation, as well as the downstream effectors of mTOR, consistent with previous reports. Knockdown of B56

Indexed as

AnimalsApoptosisCell DifferentiationCell LineCell ProliferationDown-RegulationGene Knockdown TechniquesHEK293 CellsHeLa CellsHumansMarine ToxinsMutationOkadaic AcidOxazolesPhosphorylationPolycystic Kidney Diseasescalyculin AMarine ToxinsMTOR protein, humanOkadaic AcidOxazolesPP2A-B56alpha protein, humanProtein Phosphatase 2TOR Serine-Threonine KinasesTRPP Cation Channels

Identifiers

PMID31641668
PMCPMC6770331
OpenAlexW2974096735

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.