Evidence map›Paper›PMID 31641582›Full record

ArticlePneumonia (Nathan Qld.)2015

The upper respiratory tract microbiome of hospitalised patients with community-acquired pneumonia of unknown aetiology: a pilot study.

Timothy L Wiemken, Venkatakrishna Rao Jala, Robert R Kelley, Paula Peyrani, William A Mattingly, Forest W Arnold, Patricio W Cabral, Rodrigo Cavallazzi, Bodduluri Haribabu, Julio A Ramirez

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pneumonia (Nathan Qld.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01248715 (Title), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01248715 phase4completednot on this map

Title: Effectiveness of Empiric Antiviral Treatment for Hospitalized Community Acquired Pneumonia During the Influenza Season (U18)

TypeinterventionalSponsorUniversity of LouisvilleRan2010 to 2016Enrolled1,107ConditionsInfluenza, PneumoniaArmsoseltamivir
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Timothy L Wiemken111Computational Epidemiology Unit, University of Louisville School of Medicine, Department of Medicine, Division of Infectious Diseases, Global Health Research Organization, 501 E. Broadway Suite 140B, Louisville, Kentucky 40202 USA.
Venkatakrishna Rao Jala311Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky USA.
Robert R Kelley111Computational Epidemiology Unit, University of Louisville School of Medicine, Department of Medicine, Division of Infectious Diseases, Global Health Research Organization, 501 E. Broadway Suite 140B, Louisville, Kentucky 40202 USA.
Paula Peyrani111Computational Epidemiology Unit, University of Louisville School of Medicine, Department of Medicine, Division of Infectious Diseases, Global Health Research Organization, 501 E. Broadway Suite 140B, Louisville, Kentucky 40202 USA.
William A Mattingly111Computational Epidemiology Unit, University of Louisville School of Medicine, Department of Medicine, Division of Infectious Diseases, Global Health Research Organization, 501 E. Broadway Suite 140B, Louisville, Kentucky 40202 USA.
Forest W Arnold111Computational Epidemiology Unit, University of Louisville School of Medicine, Department of Medicine, Division of Infectious Diseases, Global Health Research Organization, 501 E. Broadway Suite 140B, Louisville, Kentucky 40202 USA.
Patricio W Cabral111Computational Epidemiology Unit, University of Louisville School of Medicine, Department of Medicine, Division of Infectious Diseases, Global Health Research Organization, 501 E. Broadway Suite 140B, Louisville, Kentucky 40202 USA.
Rodrigo Cavallazzi411Division of Pulmonary, Critical Care, and Sleep Disorders Medicine, University of Louisville, Louisville, Kentucky USA.
Bodduluri Haribabu311Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky USA.
Julio A Ramirez111Computational Epidemiology Unit, University of Louisville School of Medicine, Department of Medicine, Division of Infectious Diseases, Global Health Research Organization, 501 E. Broadway Suite 140B, Louisville, Kentucky 40202 USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The composition of the upper respiratory tract microbiome may play an important role in the development of lower respiratory tract infections. Here, we characterised the microbiome of the nasopharynx and oropharynx of hospitalised patients with community-acquired pneumonia (CAP) with unknown aetiology in an attempt to obtain insight into the aetiology of CAP. A random sample of 10 patients hospitalised with CAP previously enrolled in a separate clinical trial (ClinicalTrials.gov registry, Study ID: NCT01248715) in which a complete microbiological workup was not able to define an aetiology were analysed in this pilot study. This larger trial (

Indexed as

bioinformaticsmetagenomicsmicroecologypolymerase chain reactionStreptococcus pneumoniae

Identifiers

PMID31641582
PMCPMC5922341

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.