ArticleInternational journal of retina and vitreous2019
Inverted internal limiting membrane-flap technique for large macular hole: a microperimetric study.
Article in International journal of retina and vitreous, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Evaluation of retinal functional changes after macular hole surgery using heavy brilliant blue G dye for internal limiting membrane staining: A prospective, single blind, randomized controlled trial.Indian journal of ophthalmology · 2021Trial
- Preoperative OCT Biomarkers as Predictors of Postoperative Functional Outcome Assessed by Microperimetry After Inverted ILM Flap Surgery.Diagnostics (Basel, Switzerland) · 2026Article
- Predictive Value of Preoperative Anatomical and Functional Parameters for Long-Term Visual Outcomes After Full-Thickness Macular Hole Surgery with the Inverted Flap Technique.Journal of clinical medicine · 2025Article
- Development of secondary epiretinal membrane after vitrectomy with inverted ILM flap technique to treat a macular hole.American journal of ophthalmology case reports · 2025Article
- Temporal inverted internal limiting membrane flap technique for myopic macular hole retinal detachment reconstruction.The Journal of international medical research · 2024Article
- Twenty-seven-gauge vitrectomy: a consecutive, single-centre case series with exclusive use over a 4-year period.BMC ophthalmology · 2023Article
- Biofeedback Training after Successful Inverted Internal Limiting Membrane (ILM)-Flap Technique for High Myopic Macular Hole.Journal of clinical medicine · 2023Article
- Microperimetric evaluation and predictive factors of visual recovery after successful inverted internal limiting membrane-flap technique for macular hole in high myopic eyes.Frontiers in medicine · 2023Article
- Characteristics of fixation patterns and their relationship with visual function of patients with idiopathic macular holes after vitrectomy.Scientific reports · 2021Article
- Functional evaluation with microperimetry in large idiopathic macular holes treated by a free internal limiting membrane flap tamponade technique.BMC ophthalmology · 2020Article
- Microperimetric Biofeedback Training after Successful Inverted Flap Technique for Large Macular Hole.Journal of clinical medicine · 2020Article
- Secondary Vitrectomy with Internal Limiting Membrane Plug due to Persistent Full-Thickness Macular Hole OCT-Angiography and Microperimetry Features: Case Series.Journal of ophthalmology · 2020Article
- Comparison between Cryopreserved and Dehydrated Human Amniotic Membrane Graft in Treating Challenging Cases with Macular Hole and Macular Hole Retinal Detachment.Journal of ophthalmology · 2020Article
- Current management strategies for atypical macular holes.Taiwan journal of ophthalmologyReview
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInverted Internal Limiting Membrane (ILM)-flap technique would seem to lead to higher closure rate and better visual acuity than traditional procedure with ILM peeling for the treatment of large macular hole (LMH). Visual acuity recovery does not reveal many other functional changes related to surgical approach. Our purpose was to evaluate macular function and morphology over a 1-year follow-up after inverted ILM-flap technique for LMH by using microperimetry in order to predict visual prognosis.
methodsThis study was a prospective unrandomized single-center study. 23 eyes of 22 patients with idiopathic LMH, with a minimum diameter ranging from 400 to 1000 μm, were included. All patients underwent vitrectomy with inverted ILM-flap technique and gas tamponade. We analyzed macular hole closure rate and functional outcomes including best-corrected visual acuity (BCVA), macular sensitivity (MS) at central 12° and central macular sensitivity (CMS) at central 4°, and fixation behavior as bivariate contour ellipse area (BCEA, degrees
resultsThe macular hole closure rate was 98%. The BCVA improved from 20/230 (Logmar, 1.06 ± 0.34) to 20/59 (logMar, 0.47 ± 0.45) at last follow-up (p < 0.001). Retinal sensitivity and BCEA significantly improved (MS, p = 0.001; CMS, p < 0.0001; BCEA: 68%, p < 0.01; 95%, p < 0.01; 99%, p = 0.001). Multiple stepwise regression analysis showed the final BCVA was significantly associated with macular hole size (β = 0.002, p = 0.03), preoperative MS (β = - 0.06, p = 0.001) and BCEA at 95% and 99% of fixation points (β = - 0.12, p = 0.01; β = 0.06, p = 0.01).
conclusionsInverted ILM-flap technique for LMH results in good morphologic and functional outcomes. Macular hole size and microperimetric parameters as preoperative MS and BCEA have a predictive role on post-surgical visual acuity.
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