ArticleThe World Allergy Organization journal2019
Asthma and allergic rhinitis risk depends on house dust mite specific IgE levels in PARIS birth cohort children.
Article in The World Allergy Organization journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05450289 (The Efficacy of Nigella Sativa in Children With House Dust Mite-Induced Respiratory Allergy Receiving Immunotherapy), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Efficacy of Nigella Sativa in Children With House Dust Mite-Induced Respiratory Allergy Receiving Immunotherapy
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Machine learning-derived asthma and allergy trajectories in children: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- SQ House Dust Mite Sublingual Immunotherapy Tablet in Children With Allergic Asthma: A Randomised Phase III Trial.Allergy · 2025Trial
- The Effectiveness of ProbioticNutrients · 2021Trial
- Early-Life Allergen Sensitization Phenotypes and Exploratory Machine-Learning Interpretation of School-Age Asthma Risk.Journal of asthma and allergy · 2026Article
- Distinct Profiles of Patient-Reported Outcomes Across Allergen Signatures in Chronic Rhinosinusitis.Life (Basel, Switzerland) · 2025Article
- Distinct Clinical and Cytokine Features of Moderate-Severe Persistent AR Phenotype by ARIA Classification: COCOA.Allergy, asthma & immunology research · 2025Article
- A prospective clinical study of allergy progression in identical and fraternal twin pairs of children.Translational pediatrics · 2025Article
- Efficacy and safety of SQ house dust mite sublingual immunotherapy-tablet (12 SQ-HDM) in children with allergic rhinitis/rhinoconjunctivitis with or without asthma (MT-12): a randomised, double-blind, placebo-controlled, phase III trial.The Lancet regional health. Europe · 2025Article
- Association between allergen-specific immunoglobulin E sensitization, allergic rhinitis symptoms, and quality of life in school-aged children.Scientific reports · 2024Article
- Optimization of Basophil Activation Test in the Diagnosis and Qualification for Allergen-Specific Immunotherapy in Children with Respiratory Allergy to the House Dust MiteInternational journal of molecular sciences · 2024Article
- The Prevention of House Dust Mite Allergies in Pediatric Asthma.Children (Basel, Switzerland) · 2024Review
- House dust mite allergy in Malaysia: review of research gaps in the current scenario and the way forward.Experimental & applied acarology · 2023Review
- Environmental exposure and sensitization patterns in a Swiss alpine pediatric cohort.The World Allergy Organization journal · 2023Article
- Blood eosinophil related to maternal allergic rhinitis is associated with the incidence of allergic rhinitis in offspring: COCOA study.BMC pediatrics · 2023Article
- Sensitization pattern to environmental allergens in a Japanese population.The journal of allergy and clinical immunology. Global · 2023Article
- Understanding the Functional Role of the Microbiome and Metabolome in Asthma.Current allergy and asthma reports · 2023Review
- Allergic sensitization trajectories to age 8 years in the Singapore GUSTO cohort.The World Allergy Organization journal · 2022Article
- Association between allergic sensitization and intestinal parasite infection in schoolchildren in Gqeberha, South Africa.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022Article
- Characterization of allergic inflammation in chronic uterine cervicitis.Clinical and experimental immunology · 2022Article
- Development of Sensitization to Multiple Allergen Molecules from Preschool to School Age Is Related to Asthma.International archives of allergy and immunology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe natural history of allergic sensitization in childhood, and its impact on allergic disease development, needs to be clarified. This study aims to identify allergic sensitization and morbidity patterns during the first 8 years of life.
methodsThe study was conducted in the on-going population-based prospective Pollution and Asthma Risk: an Infant Study (PARIS) birth cohort. Sensitization profiles were identified by k-means clustering based upon allergen-specific IgE levels measured at 18 months and 8/9 years. Allergic morbidity profiles were identified by latent class analysis based on symptoms, symptom severity, treatments, and lifetime doctor-diagnoses of asthma, allergic rhinitis, and atopic dermatitis and on lower respiratory infections before 2 years.
resultsFive sensitization and 5 allergic morbidity patterns were established in 714 children. Children not sensitized or with isolated and low allergen-specific sensitization were grouped together (76.8%). A profile of early and transient sensitization to foods that increased the risk of asthma later in childhood was identified (4.9%). Children strongly sensitized (≥3.5 kU CONCLUSIONS & CLINICAL RELEVANCE: We show that accurate assessment of the risk of allergic disease should rely on earliness and multiplicity of sensitization, involved allergens, and allergen-specific IgE levels, and not considering solely allergic sensitization as a dichotomous variable (allergen-specific IgE ≥0.35 kU
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.