Evidence map›Paper›PMID 31641354›Full record

ArticleJournal of oncology2019

Human Papillomavirus and Anal Cancer: Prevalence, Genotype Distribution, and Prognosis Aspects from Midwestern Region of Brazil.

Larisse Silva Dalla Libera, Keila Patrícia Almeida de Carvalho, Jéssica Enocencio Porto Ramos, Lázara Alyne Oliveira Cabral, Rita de Cassia Goncalves de Alencar, Luísa Lina Villa, Rosane Ribeiro Figueiro Alves, Silvia Helena Rabelo Santos, Megmar Aparecida Dos Santos Carneiro, Vera Aparecida Saddi

Open access · hybridAbstract read
In one paragraph

Article in Journal of oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Larisse Silva Dalla LiberaUniversidade Federal de Goiás, Postgraduate Program in Health Sciences, Faculty of Medicine, Goiânia, Goiás, CEP 74605-020, Brazil.ORCID https://orcid.org/0000-0003-3437-7458
Keila Patrícia Almeida de CarvalhoUniversidade Federal de Goiás, Institute of Tropical Pathology and Public Health, Goiânia, Goiás, CEP 74605-050, Brazil.
Jéssica Enocencio Porto RamosPontifical Catholic University of Goiás, Postgraduate Program in Environmental Sciences and Health, Goiânia, Goiás, CEP 74605-010, Brazil.
Lázara Alyne Oliveira CabralPontifical Catholic University of Goiás, Postgraduate Program in Environmental Sciences and Health, Goiânia, Goiás, CEP 74605-010, Brazil.
Rita de Cassia Goncalves de AlencarDepartment of Pathology, Hospital Araújo Jorge, Goiânia, Goiás, CEP 74605-050, Brazil.
Luísa Lina VillaCancer Institute of the State of São Paulo, São Paulo, SP, CEP 01246-000, Brazil.
Rosane Ribeiro Figueiro AlvesUniversidade Federal de Goiás, Postgraduate Program in Health Sciences, Faculty of Medicine, Goiânia, Goiás, CEP 74605-020, Brazil.
Silvia Helena Rabelo SantosUniversidade Federal de Goiás, Institute of Tropical Pathology and Public Health, Goiânia, Goiás, CEP 74605-050, Brazil.
Megmar Aparecida Dos Santos CarneiroUniversidade Federal de Goiás, Institute of Tropical Pathology and Public Health, Goiânia, Goiás, CEP 74605-050, Brazil.
Vera Aparecida SaddiUniversidade Federal de Goiás, Postgraduate Program in Health Sciences, Faculty of Medicine, Goiânia, Goiás, CEP 74605-020, Brazil.ORCID https://orcid.org/0000-0001-9949-9988
Universidade Federal de Goiás · BRPontifícia Universidade Católica de Goiás · BRHospital Araújo Jorge · BRInstituto do Câncer do Estado de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundApproximately 90% of all anal cancers are associated with human papillomavirus (HPV), especially high-risk genotypes such as HPVs 16 and 18.

objectiveTo investigate the clinical and prognostic aspects of anal cancers associated with the presence, as well as the genotypic distribution of human papillomavirus (HPV).

methodsA retrospective study carried out over a 10-year period, using clinical and molecular data, with PCR analysis and reverse hybridization (INNO-LIPA kit), in anal cancers. The data analysis was done using descriptive univariate statistics, and the survival curves were made using the Kaplan-Meier and log-rank methods.

resultsOf the 81 formalin-fixed and paraffin-embedded specimens, HPV prevalence was 69% and was significantly higher in squamous cell carcinomas (SCC) than in other anal tumors (

conclusionsThe association of HPV to anal cancer was found in this study, especially in SCC. However, the presence of HPV did not influence the prognosis of patients with anal cancer.

Identifiers

PMID31641354
PMCPMC6766672
OpenAlexW2974507340

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.