Trial reportScientific reports2019
Calibrated interdental brushing for the prevention of periodontal pathogens infection in young adults - a randomized controlled clinical trial.
Trial report in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Periodontal disease is associated with the risk of cardiovascular disease independent of sex: A meta-analysis.Frontiers in cardiovascular medicine · 2023Pooled it
- Impact of Interdental Brushing on Pregnancy-Associated Gingivitis: A Secondary Analysis of a Randomised Controlled Trial.Journal of clinical periodontology · 2026Trial
- Interdental Brushing and Obstetrical Outcomes in Nulliparous Pregnant Women: Insights From a Cluster Randomised Controlled Trial.Journal of clinical periodontology · 2026Trial
- Interdental plaque reduction after the use of different devices in patients with periodontitis and interdental recession: A randomized clinical trial.International journal of dental hygiene · 2022Trial
- Oral Hygiene Behaviors, Periodontal Awareness, and Self-Reported Periodontal Symptoms Among Adults: A Cross-Sectional Survey Study.Healthcare (Basel, Switzerland) · 2026Article
- Interdental brushes for improving oral hygiene in patients with fixed orthodontic appliances: a systematic review.Frontiers in oral health · 2026Review
- Planetary health diet with einkorn as a potential preventive strategy to improve interdental microbiota, oral health and quality of life: a pilot clinical trial.Journal of oral microbiology · 2026Article
- Oral prophylaxis for the reduction of interdental dysbiosis-associated red complex pathogens during pregnancy: a randomized clinical trial.Frontiers in medicine · 2026Article
- Effectiveness of Different Methods of Interdental Hygiene in Daily Practice Among Young Adults: Protocol for a Randomized, Single-Blind Controlled Trial.JMIR research protocols · 2025Article
- Improved Plaque-Induced Gingivitis in Students Using Calibrated Interdental Brushes: Results of a 3-Month Multicenter Educational Intervention.Journal of clinical medicine · 2025Article
- The Relationship Between Processed Food Consumption and Periodontal Disease: Sex Disparities in the Majorcan Adolescent Population.Life (Basel, Switzerland) · 2025Article
- Effect of toothbrush type on biofilm and periodontal health in orthodontic patients.Bioinformation · 2025Article
- Article
- The impact of prebiotics and probiotics on the oral microbiome of individuals with periodontal disease: a scoping review.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2024Article
- Effects of Sucrose and Farnesol on Biofilm Formation byMicroorganisms · 2024Article
- Smartphone Applications in Dentistry: A Scoping Review.Dentistry journal · 2023Article
- Periodontal Pathogens and Their Links to Neuroinflammation and Neurodegeneration.Microorganisms · 2023Review
- Prevalence, Severity of Extension, and Risk Factors of Gingivitis in a 3-Month Pregnant Population: A Multicenter Cross-Sectional Study.Journal of clinical medicine · 2023Article
- Oral hygiene, mouthwash usage and cardiovascular mortality during 18.8 years of follow-up.British dental journal · 2023Article
- Periodontal pathogens of the interdental microbiota in a 3 months pregnant population with an intact periodontium.Frontiers in microbiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontal disease is clearly correlated with systemic disease. The presence of periodontal pathogens in interdental spaces in young, healthy adults is a strong indicator of the need to introduce daily interdental prophylaxis. Twenty-five subjects (aged 18-35 years), diagnosticated clinically as periodontally healthy, were enrolled in this study. One hundred interdental sites were included. Among these sites, 50 "test" sites were cleaned daily with calibrated interdental brushes (IDBs), whereas the other 50 sites were not cleaned and considered "controls". The interdental biofilm at these interdental sites was collected at the beginning of the study (basal) and at 1 week, 2 weeks, 3 weeks, 4 weeks, and 3 months. Real-time polymerase chain reaction (PCR) methodology was used to quantify (i) 19 periodontal bacteria, including Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia, and (ii) total bacteria. In the test sites, the quantity of total bacteria decreased over time with the use of IDBs. The bacteria from the red and orange Socransky complexes, which are associated with periodontal disease, significantly decreased in the test sites but not in the control sites. Bacteria from the yellow, and purple Socransky complexes, which are associated with periodontal health, increased significantly in both groups whereas bacteria from the blue Socransky complex increased significantly only in the test sites. Furthermore, at basal, 66% of test sites and 68% of control sites bled during interdental brushing. These percentages decreased by 85% in 3 months for the test sites and by 27% in the control sites. In conclusion, the daily use of calibrated IDBs can reduce periodontal pathogens, reestablish symbiotic microbiota and, decrease interdental inflammation in interdental sites of healthy young adults.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.