ArticleScientific reports2019
Quantification of total haemoglobin concentrations in human whole blood by spectroscopic visible-light optical coherence tomography.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Label-free assessment of a microfluidic vessel-on-chip model with visible-light optical tomography reveals structural changes in vascular networks.Lab on a chip · 2026Article
- Non-invasive quantification of total hemoglobin concentrations by visible-light spectroscopic optical coherence tomography: a validation study on healthy volunteers.Biomedical optics express · 2025Article
- Design and characterization of color printed polyurethane films as biomedical phantom layers.Biomedical optics express · 2023Article
- Adaptive spectroscopic visible-light optical coherence tomography for clinical retinal oximetry.Communications medicine · 2023Article
- Multiple forward scattering reduces the measured scattering coefficient of whole blood in visible-light optical coherence tomography.Biomedical optics express · 2022Article
- Precision of attenuation coefficient measurements by optical coherence tomography.Journal of biomedical optics · 2022Article
- High-Speed Balanced-Detection Visible-Light Optical Coherence Tomography in the Human Retina Using Subpixel Spectrometer Calibration.IEEE transactions on medical imaging · 2022Article
- Optical density based quantification of total haemoglobin concentrations with spectroscopic optical coherence tomography.Scientific reports · 2021Article
- Intrinsic spectrally-dependent background in spectroscopic visible-light optical coherence tomography.Biomedical optics express · 2021Article
- Visible light optical coherence tomography angiography (vis-OCTA) facilitates local microvascular oximetry in the human retina.Biomedical optics express · 2020Article
- Spectrally dependent roll-off in visible-light optical coherence tomography.Optics letters · 2020Article
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Authors and funding
6 authors.
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Abstract
The non-invasive quantification of total haemoglobin concentrations [tHb] is highly desired for the assessment of haematologic disorders in vulnerable patient groups, but invasive blood sampling is still the gold standard in current clinical practice. This work demonstrates the potential of visible-light spectroscopic optical coherence tomography (sOCT) for quantifying the [tHb] in human whole blood. To accurately quantify the [tHb] from the substantial optical attenuation by blood in the visible wavelength range, we used a combination of zero-delay acquisition and focus tracking that ensures optimal system sensitivity at any depth inside the sample. Subsequently, we developed an analysis model to adequately correct for the high scattering contribution by red blood cells to the sOCT signal. We validate our method and compare it to conventional sOCT (without focus tracking and zero-delay acquisition) through ex-vivo measurements on flowing human whole blood, with [tHb] values in the clinical range of 7-23 g/dL. For our method with optimized sensitivity, the measured and expected values correlate well (Pearson correlation coefficient = 0.89, p < 0.01), with a precision of 3.8 g/dL. This is a considerable improvement compared to conventional sOCT (Pearson correlation coefficient = 0.59, p = 0.16; precision of 9.1 g/dL).
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