ArticleScientific reports2019
Response Latency Tuning by Retinal Circuits Modulates Signal Efficiency.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Inhibitory Circuits Can Restore OFF Pathway Responses in Retinal Prostheses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Synergistic Geniculate and Cortical Dynamics Facilitate a Decorrelated Spatial Frequency Code in the Early Visual System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Synchronization of visual perception within the human fovea.Nature neuroscience · 2025Article
- Neurophysiological measurements of planarian brain activity: a unique model for neuroscience research.Biology open · 2024Article
- Gap junctions fine-tune ganglion cell signals to equalize response kinetics within a given electrically coupled array.iScience · 2024Article
- Defining morphologically and genetically distinct GABAergic/cholinergic amacrine cell subtypes in the vertebrate retina.PLoS biology · 2024Article
- Article
- Review
- The role of gap junctions in cell death and neuromodulation in the retina.Neural regeneration research · 2021Review
- LED-Induced Microglial Activation and Rise in Caspase3 Suggest a Reorganization in the Retina.International journal of molecular sciences · 2021Article
- Neuromodulation using electroosmosis.Journal of neural engineering · 2021Article
- Spatial Expression Pattern of the Major CaCells · 2020Article
- Electrical Imaging of Light-Induced Signals Across and Within Retinal Layers.Frontiers in neuroscience · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the visual system, retinal ganglion cells (RGCs) of various subtypes encode preprocessed photoreceptor signals into a spike output which is then transmitted towards the brain through parallel feature pathways. Spike timing determines how each feature signal contributes to the output of downstream neurons in visual brain centers, thereby influencing efficiency in visual perception. In this study, we demonstrate a marked population-wide variability in RGC response latency that is independent of trial-to-trial variability and recording approach. RGC response latencies to simple visual stimuli vary considerably in a heterogenous cell population but remain reliable when RGCs of a single subtype are compared. This subtype specificity, however, vanishes when the retinal circuitry is bypassed via direct RGC electrical stimulation. This suggests that latency is primarily determined by the signaling speed through retinal pathways that provide subtype specific inputs to RGCs. In addition, response latency is significantly altered when GABA inhibition or gap junction signaling is disturbed, which further supports the key role of retinal microcircuits in latency tuning. Finally, modulation of stimulus parameters affects individual RGC response delays considerably. Based on these findings, we hypothesize that retinal microcircuits fine-tune RGC response latency, which in turn determines the context-dependent weighing of each signal and its contribution to visual perception.
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