Evidence map›Paper›PMID 31641116›Full record

ArticleNature communications2019

Sub-nanomolar sensitive GZnP3 reveals TRPML1-mediated neuronal Zn

Taylor F Minckley, Chen Zhang, Dylan H Fudge, Anna M Dischler, Kate D LeJeune, Haoxing Xu, Yan Qin

Abstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
  2. Redesign of Calmodulin for Genetically Encoded ZnChemical & biomedical imaging · 2026
    Article
  3. Article
  4. Article
  5. Metallothionein III Mediates CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. The ion channels of endomembranes.Physiological reviews · 2024
    Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Genetically encoded fluorescent sensors for metals in biology.Current opinion in chemical biology · 2023
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Taylor F MinckleyDepartment of Biological Sciences, University of Denver, Denver, CO, 80210, USA.ORCID http://orcid.org/0000-0002-5658-4979
Chen ZhangDepartment of Biological Sciences, University of Denver, Denver, CO, 80210, USA.
Dylan H FudgeDepartment of Biological Sciences, University of Denver, Denver, CO, 80210, USA.
Anna M DischlerDepartment of Biological Sciences, University of Denver, Denver, CO, 80210, USA.
Kate D LeJeuneDepartment of Biological Sciences, University of Denver, Denver, CO, 80210, USA.
Haoxing XuDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 4114 Biological Sciences Building, 1105 North University, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0003-3561-4654
Yan QinDepartment of Biological Sciences, University of Denver, Denver, CO, 80210, USA. yan.qin@du.edu.ORCID http://orcid.org/0000-0003-3640-0105

Funding

The Mucolipin TRP Ion ChannelsR01NS062792 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, HAOXING · 2009 to 2018
$3.3M
Regulations of organellar Zn2+ homeostasis and dynamics by TRPML1 in neuronsR01NS110590 · NINDS · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI QIN, YAN · 2019 to 2023
$1.6M
Ion channels in the tubulovesiclesR01DK115474 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AKAABOUNE, MOHAMMED, DU, WANLU · 2018 to 2022
$1.4M
Generation of Cell-based and Animal-based Imaging Systems for Monitoring SynapticR00EB017289 · NIBIB · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI QIN, YAN · 2016 to 2018
$660k
Generation of Cell-based and Animal-based Imaging Systems for Monitoring SynapticK99EB017289 · NIBIB · UNIVERSITY OF COLORADO · PI QIN, YAN · 2014 to 2015
$97k
PHAGOCYTOSIS OF THE AMYLOID BETA PEPTIDE BY MICROGLIAR03AG017289 · NIA · UNIVERSITY OF CALIFORNIA IRVINE · PI WEBSTER, SCOTT D. · 1999 to 1999
–
NIBIB NIH HHS K99 EB017289NIBIB NIH HHS R00 EB017289NIDDK NIH HHS R01 DK115474NINDS NIH HHS R01 NS062792NINDS NIH HHS R01 NS110590U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB) R00EB017289U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS062792U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS110590
6 · The paper itself

Abstract

Although numerous fluorescent Zn

Indexed as

AnimalsBiological TransportCalciumCells, CulturedCytosolFemaleFluorescent DyesLysosomesNeuronsRatsRats, Sprague-DawleyTransient Receptor Potential ChannelsZincCalciumFluorescent DyesMcoln1 protein, ratTransient Receptor Potential ChannelsZinc

Identifiers

PMID31641116
PMCPMC6805855

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.