Evidence map›Paper›PMID 31641049›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease.

Mona Lei, Jonathan D Teo, Huitong Song, Holly P McEwen, Jun Yup Lee, Timothy A Couttas, Thomas Duncan, Rose Chesworth, Josefine Bertz, Magdalena Przybyla and 9 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  6. Article
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  8. Article
  9. Review
  10. Glial Sphingosine-Mediated Epigenetic Regulation Stabilizes Synaptic Function inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  11. Review
  12. Sphingosine kinases regulate ER contacts with late endocytic organelles and cholesterol trafficking.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  13. Transgenic Mouse Models of Alzheimer's Disease: An Integrative Analysis.International journal of molecular sciences · 2022
    Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Ferroptosis, a Potential Therapeutic Target in Alzheimer's Disease.Frontiers in cell and developmental biology · 2021
    Review
  20. The Functional Role of Sphingosine Kinase 2.Frontiers in molecular biosciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 2 countries.

Mona LeiCentenary Institute, University of Sydney, Camperdown 2006, New South Wales, Australia.
Jonathan D TeoCentenary Institute, University of Sydney, Camperdown 2006, New South Wales, Australia.
Huitong SongCentenary Institute, University of Sydney, Camperdown 2006, New South Wales, Australia.
Holly P McEwenCentenary Institute, University of Sydney, Camperdown 2006, New South Wales, Australia.
Jun Yup LeeCentenary Institute, University of Sydney, Camperdown 2006, New South Wales, Australia.
Timothy A CouttasCentenary Institute, University of Sydney, Camperdown 2006, New South Wales, Australia.
Thomas DuncanBrain and Mind Centre, Sydney Medical School, University of Sydney, Camperdown 2006, New South Wales, Australia.
Rose ChesworthSchool of Medicine, Western Sydney University, Campbelltown 2560, New South Wales, Australia.
Josefine BertzDementia Research Centre, Faculty of Health and Medical Sciences.
Magdalena PrzybylaDementia Research Centre, Faculty of Health and Medical Sciences.
Janet Van EerselDementia Research Centre, Faculty of Health and Medical Sciences.
Benjamin HengMND Research Centre, Neuroinflammation Group, Macquarie University, Sydney 2109, New South Wales, Australia.
Gilles J GuilleminMND Research Centre, Neuroinflammation Group, Macquarie University, Sydney 2109, New South Wales, Australia.ORCID 0000-0001-8105-4470
Lars M IttnerDementia Research Centre, Faculty of Health and Medical Sciences.
Thomas FathDementia Research Centre, Faculty of Health and Medical Sciences.
Brett GarnerIllawarra Health and Medical Research Institute.
Arne IttnerDementia Research Centre, Faculty of Health and Medical Sciences.
Tim KarlSchool of Medicine, Western Sydney University, Campbelltown 2560, New South Wales, Australia.
Anthony S DonCentenary Institute, University of Sydney, Camperdown 2006, New South Wales, Australia, anthony.don@sydney.edu.au.ORCID 0000-0003-1655-1184
The University of Sydney · AUDementia UK · GBCamden and Campbelltown Hospitals · AUMacquarie University · AUUniversity of Wollongong · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sphingosine 1-phosphate (S1P) is a potent vasculoprotective and neuroprotective signaling lipid, synthesized primarily by sphingosine kinase 2 (SK2) in the brain. We have reported pronounced loss of S1P and SK2 activity early in Alzheimer's disease (AD) pathogenesis, and an inverse correlation between hippocampal S1P levels and age in females, leading us to speculate that loss of S1P is a sensitizing influence for AD. Paradoxically, SK2 was reported to mediate amyloid β (Aβ) formation from amyloid precursor protein (APP)

Indexed as

Disease Models, AnimalAlzheimer DiseaseAnimalsDemyelinating DiseasesFemaleHippocampusMaleMiceMice, TransgenicNeuroprotectionOrgan Culture TechniquesOrgan SizePhosphotransferases (Alcohol Group Acceptor)Plaque, AmyloidSphingosine KinasePhosphotransferases (Alcohol Group Acceptor)Sphingosine Kinasesphingosine kinase 2, mouseAlzheimer's diseasemyelinneuroprotectionoligodendrocytesphingosine 1-phosphatesphingosine kinase

Identifiers

PMID31641049
PMCPMC6880469
OpenAlexW2982160829

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.