Evidence map›Paper›PMID 31641048›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Contribution of the Retrotrapezoid Nucleus and Carotid Bodies to Hypercapnia- and Hypoxia-induced Arousal from Sleep.

George M P R Souza, Ruth L Stornetta, Daniel S Stornetta, Stephen B G Abbott, Patrice G Guyenet

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Article
  3. Sleep, Neural Circulatory Control, and Cardiovascular Disease: A Mechanistic Review.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  4. Oxygen-based endotypes of Obstructive Sleep Apnea.medRxiv : the preprint server for health sciences · 2026
    Article
  5. Article
  6. Review
  7. Respiratory Depression Associated with Opioids: A Narrative Review.Current treatment options in oncology · 2024
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Kir5.1 channels: potential role in epilepsy and seizure disorders.American journal of physiology. Cell physiology · 2022
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

George M P R SouzaDepartment of Pharmacology, University of Virginia, Charlottesville, Virginia 22908.ORCID 0000-0003-4678-6910
Ruth L StornettaDepartment of Pharmacology, University of Virginia, Charlottesville, Virginia 22908.ORCID 0000-0001-7278-8923
Daniel S StornettaDepartment of Pharmacology, University of Virginia, Charlottesville, Virginia 22908.ORCID 0000-0002-5570-6276
Stephen B G AbbottDepartment of Pharmacology, University of Virginia, Charlottesville, Virginia 22908 sba6t@virginia.edu.ORCID 0000-0003-1244-3637
Patrice G GuyenetDepartment of Pharmacology, University of Virginia, Charlottesville, Virginia 22908.ORCID 0000-0003-1739-2306
University of Virginia · US

Funding

Retrotrapezoid nucleus and central chemoreceptionR01HL074011 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GUYENET, PATRICE G. · 2003 to 2018
$6.6M
Organization of Central Sympathic PathwaysR01HL028785 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI STORNETTA, RUTH L · 1985 to 2020
$5.0M
ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYSR37HL028785 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GUYENET, PATRICE G. · 1999 to 2008
$3.0M
Role of presympathetic neurons of the hindbrain in cardiovascular controlR01HL148004 · NHLBI · UNIVERSITY OF VIRGINIA · PI ABBOTT, STEPHEN · 2019 to 2023
$2.6M
NHLBI NIH HHS R01 HL028785NHLBI NIH HHS R01 HL074011NHLBI NIH HHS R01 HL148004NHLBI NIH HHS R37 HL028785
6 · The paper itself

Abstract

The combination of hypoxia and hypercapnia during sleep produces arousal, which helps restore breathing and normalizes blood gases. Hypercapnia and hypoxia produce arousal in mammals by activating central (pH-sensitive) and peripheral (primarily O

Indexed as

ArousalAnimalsBlood Gas AnalysisBlood PressureCarotid BodyElectroencephalographyElectromyographyHydrogen-Ion ConcentrationHypercapniaHypoxiaMaleMedulla OblongataPlethysmographyRatsRats, Sprague-DawleyRespiratory Mechanicsarousal systemschemoreceptionhypercapniahypoxiarespirationsleep apnea

Identifiers

PMID31641048
PMCPMC6891059
OpenAlexW2981993576

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.