Evidence map›Paper›PMID 31640987›Full record

ArticleThe Journal of biological chemistry2019

Structural and biophysical characterizations of HIV-1 matrix trimer binding to lipid nanodiscs shed light on virus assembly.

R Elliot Murphy, Alexandra B Samal, Jiri Vlach, Vicente Mas, Peter E Prevelige, Jamil S Saad

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. The conserved HIV-1 spacer peptide 2 triggers matrix lattice maturation.bioRxiv : the preprint server for biology · 2024
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Atomic view of the HIV-1 matrix lattice; implications on virus assembly and envelope incorporation.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

R Elliot MurphyDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294.
Alexandra B SamalDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294.
Jiri VlachDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294.
Vicente MasCentro Nacional de Microbiología and CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, 28029 Madrid, Spain.
Peter E PreveligeDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294.
Jamil S SaadDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294. Electronic address: saad@uab.edu.

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Omer Jamy · 1985 to 2026
$165.9M
Structural basis for HIV-1 Gag interactions with cellular and viral constituentsR01AI150901 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Terje Dokland · 2019 to 2026
$2.9M
Structural Basis for HIV-1 Gag Interactions with Cellular ConstituentsR01GM117837 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SAAD, JAMIL SUBHI · 2015 to 2018
$1.7M
MicroCal Auto-iTC200; automated high sensitivity isothermal titration calorimetryS10RR026478 · NCRR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BROUILLETTE, CHRISTIE G. · 2010 to 2010
$250k
NCI NIH HHS P30 CA013148NCRR NIH HHS S10 RR026478NIAID NIH HHS R01 AI150901NIGMS NIH HHS R01 GM117837
6 · The paper itself

Abstract

During the late phase of the HIV-1 replication cycle, the viral Gag polyproteins are targeted to the plasma membrane for assembly. The Gag-membrane interaction is mediated by binding of Gag's N-terminal myristoylated matrix (MA) domain to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P

Indexed as

CalorimetryCell MembraneGene Products, gagHIV-1HIV Envelope Protein gp41Magnetic Resonance SpectroscopyPhosphatidylserinesProtein BindingVirus AssemblyGene Products, gagHIV Envelope Protein gp41PhosphatidylserinesFabGag proteinhuman immunodeficiency virus (HIV)isothermal titration calorimetry (ITC)mass spectrometry (MS)myristoylated matrix (MA)nanodisc (ND)nuclear magnetic resonance (NMR)phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)phosphatidylserine (PS)plasma membrane

Identifiers

PMID31640987
PMCPMC6901326

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.