Evidence map›Paper›PMID 31640985›Full record

ArticleThe Journal of biological chemistry2019

The telomere-binding protein Rif2 and ATP-bound Rad50 have opposing roles in the activation of yeast Tel1

Sarem Hailemariam, Paolo De Bona, Roberto Galletto, Marcel Hohl, John H Petrini, Peter M Burgers

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Rap1-mediated steric hindrance protects telomeres from MRX sensing.Nature structural & molecular biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Dynamic Properties of the DNA Damage Response Mre11/Rad50 Complex.International journal of molecular sciences · 2023
    Review
  7. Review
  8. Article
  9. Novel insights into the mechanism of cell cycle kinases Mec1(ATR) and Tel1(ATM).Critical reviews in biochemistry and molecular biology · 2021
    Article
  10. Article
  11. Article
  12. Article
  13. Mechanism of auto-inhibition and activation of Mec1Nature structural & molecular biology · 2021
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sarem HailemariamDepartment of Biochemistry and Molecular Biophysics, Washington University in St. Louis, St. Louis, Missouri 63110.
Paolo De BonaDepartment of Biochemistry and Molecular Biophysics, Washington University in St. Louis, St. Louis, Missouri 63110.
Roberto GallettoDepartment of Biochemistry and Molecular Biophysics, Washington University in St. Louis, St. Louis, Missouri 63110. Electronic address: galletto@wustl.edu.
Marcel HohlMolecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
John H PetriniMolecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
Peter M BurgersDepartment of Biochemistry and Molecular Biophysics, Washington University in St. Louis, St. Louis, Missouri 63110. Electronic address: burgers@wustl.edu.
Washington University in St. Louis · USMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
MSKCC Pilot Center for Precision Disease ModelingU54OD020355 · OD · SLOAN-KETTERING INST CAN RESEARCH · PI LOWE, SCOTT W., SOLIT, DAVID B. · 2015 to 2019
$9.9M
MECHANISMS OF DNA REPLICATION AND MAINTENANCE IN EUKARYOTESR35GM118129 · NIGMS · WASHINGTON UNIVERSITY · PI BURGERS, PETER M · 2016 to 2025
$6.7M
Regulation of the DNA damage response by the Mre11 complexR37GM059413 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI PETRINI, JOHN HJ · 2012 to 2020
$5.2M
The Mre11 complex: linking recombination to checkpointsR01GM059413 · NIGMS · UNIVERSITY OF WISCONSIN MADISON · PI PETRINI, JOHN HJ · 1999 to 2011
$5.2M
HELICASE ACTIVITY AND ITS ROLE IN TELOMERE AND TELOMERASE REGULATIONR01GM098509 · NIGMS · WASHINGTON UNIVERSITY · PI GALLETTO, ROBERTO · 2011 to 2020
$2.7M
NCI NIH HHS P30 CA008748NIGMS NIH HHS R01 GM059413NIGMS NIH HHS R01 GM098509NIGMS NIH HHS R35 GM118129NIGMS NIH HHS R37 GM059413NIH HHS U54 OD020355
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA-Binding ProteinsIntracellular Signaling Peptides and ProteinsProtein Serine-Threonine KinasesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTelomereTelomere-Binding ProteinsDNA-Binding ProteinsIntracellular Signaling Peptides and ProteinsProtein Serine-Threonine KinasesRAD50 protein, S cerevisiaeRIF2 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsTEL1 protein, S cerevisiaeTelomere-Binding Proteinsataxia telangiectasiaATM kinaseATPasecell cycle checkpointcheckpoint controlDNA damage responsedouble-stranded breakMRXRad50 ATPaseRif2Tel1 kinasetelomeretelomere control

Identifiers

PMID31640985
PMCPMC6901328
OpenAlexW2981678013

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.