ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2019
Burden of varicella complications in secondary care, England, 2004 to 2017.
Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Healthcare resource use and costs of varicella and its complications: A systematic literature review.Human vaccines & immunotherapeutics · 2023Pooled it
- Pooled it
- Geographic and age-specific trends in vaccine-preventable diseases in Qatar: A primary health care-based study (2021-2024).Qatar medical journal · 2026Article
- Trends and patterns of varicella zoster virus infection in Kilifi: A population-based serosurvey.PLOS global public health · 2026Article
- Review
- Managing Neonatal Varicella: A Case Series Highlighting the Effectiveness of Antiviral Therapy Without IVIG.Children (Basel, Switzerland) · 2025Article
- The Clinical and Economic Burden of Antibiotic Use in Pediatric Patients With Varicella Infection: A Retrospective Cohort Analysis of Real-World Data in England.The Journal of infectious diseases · 2024Article
- Burden of chickenpox complications in Poland, 2006 to 2021: A comprehensive registry-based study.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024Article
- Global Prevalence of Varicella-Associated Complications: A Systematic Review and Meta-Analysis.Infectious diseases and therapy · 2024Article
- The Epidemiology of Chickenpox in England, 2016-2022: An Observational Study Using General Practitioner Consultations.Viruses · 2023Observational
- Estimating the health economic impact of the universal varicella vaccination in Argentina from 2015 to 2019.Human vaccines & immunotherapeutics · 2023Article
- Maternal varicella antibodies in children aged less than one year: Assessment of antibody decay.PloS one · 2023Article
- Epidemiological analysis of varicella in Dalian from 2009 to 2019 and application of three kinds of model in prediction prevalence of varicella.BMC public health · 2022Article
- Pediatric Hospitalization for Varicella in an Italian Pediatric Hospital: How Much Does It Cost?International journal of environmental research and public health · 2021Article
- Survey among Italian experts on existing vaccines' role in limiting antibiotic resistance.Human vaccines & immunotherapeutics · 2021Article
- Economic evaluation of varicella vaccination strategies in Jiangsu province, China: a decision-tree Markov model.Human vaccines & immunotherapeutics · 2021Article
- Acceptance of varicella vaccination.Human vaccines & immunotherapeutics · 2021Article
- Adult Chickenpox.Internal medicine (Tokyo, Japan) · 2020Article
- Varicella zoster virus encodes a viral decoy RHIM to inhibit cell death.PLoS pathogens · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BackgroundStrategies to control varicella vary across Europe. Evidence from established programmes has prompted the United Kingdom to re-evaluate the need for universal vaccination. The burden of complicated varicella is a key parameter in the cost-effectiveness analysis.AimOur objective was to estimate the burden of complicated varicella in England.MethodsThis electronic health record surveillance study used data from all NHS hospitals in England to identify varicella admissions between 2004 and 2017. The incidence of pre-defined complications of varicella was estimated using ICD-10 codes. Inpatient costs were calculated based on the payment rules for providers of NHS services.ResultsThere were 61,024 admissions with varicella between 2004 and 2017 and 38.1% had a recognised varicella complication. Incidence of hospitalisation increased by 25% and the proportion with complicated varicella by 24% from 2004/05 to 2016/17. The most common complications were bacterial skin infections (11.25%), pneumonia (4.82%), febrile convulsions (3.39%) and encephalitis (2.44%). Complication rates were higher in older age groups and the type of complications more severe. Length of stay for complicated varicella was 3.1 times longer than for uncomplicated varicella and inpatient costs were 72% greater.ConclusionComplicated varicella has a substantial health and economic burden. These data together with data on impact on quality of life are important in informing the cost-effectiveness analysis of universal varicella vaccination.
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