Evidence map›Paper›PMID 31640839›Full record

ReviewTwin research and human genetics : the official journal of the International Society for Twin Studies2019

FinnTwin12 Cohort: An Updated Review.

Richard J Rose, Jessica E Salvatore, Sari Aaltonen, Peter B Barr, Leonie H Bogl, Holly A Byers, Kauko Heikkilä, Tellervo Korhonen, Antti Latvala, Teemu Palviainen and 5 more

Open access · hybridAbstract readReviewTwin Study
In one paragraph

Review in Twin research and human genetics : the official journal of the International Society for Twin Studies, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 3 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 104 citations in OpenAlex.

  1. Pooled it
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  5. The effect of obesity and aging on NADInternational journal of obesity (2005) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

Richard J RoseDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.
Jessica E SalvatoreDepartment of Psychology, Virginia Commonwealth University, Richmond, VA, USA.
Sari AaltonenInstitute for Molecular Medicine FIMM, Helsinki, Finland.
Peter B BarrDepartment of Psychology, Virginia Commonwealth University, Richmond, VA, USA.
Leonie H BoglInstitute for Molecular Medicine FIMM, Helsinki, Finland.
Holly A ByersDepartment of Psychology, Virginia Commonwealth University, Richmond, VA, USA.
Kauko HeikkiläInstitute for Molecular Medicine FIMM, Helsinki, Finland.
Tellervo KorhonenInstitute for Molecular Medicine FIMM, Helsinki, Finland.
Antti LatvalaInstitute for Molecular Medicine FIMM, Helsinki, Finland.
Teemu PalviainenInstitute for Molecular Medicine FIMM, Helsinki, Finland.
Anu RanjitDepartment of Public Health, University of Helsinki, Helsinki, Finland.
Alyce M WhippInstitute for Molecular Medicine FIMM, Helsinki, Finland.
Lea PulkkinenDepartment of Psychology, University of Jyvaskyla, Jyvaskyla, Finland.
Danielle M DickDepartment of Psychology, Virginia Commonwealth University, Richmond, VA, USA.
Jaakko KaprioInstitute for Molecular Medicine FIMM, Helsinki, Finland.
Institute for Molecular Medicine Finland · FIVirginia Commonwealth University · USUniversity of Helsinki · FIIndiana University Bloomington · USUniversity of Jyväskylä · FI

Funding

The development of alcohol misuse and related problems from adolescence to early midlifeR01AA015416 · NIAAA · WASHINGTON UNIVERSITY · PI DICK, DANIELLE M, SALVATORE, JESSICA E · 2005 to 2024
$7.6M
Twin, molecular, and developmental approaches to understanding alcohol misuseK02AA018755 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DICK, DANIELLE M · 2010 to 2019
$1.3M
Adolescent Alcohol Abuse: A Twin-Study PerspectiveR01AA012502 · NIAAA · TRUSTEES OF INDIANA UNIVERSITY · PI ROSE, RICHARD JOSEPH · 2013 to 2017
$1.2M
Genetics, Romantic Relationships, and Alcohol Misuse in Emerging AdulthoodK01AA024152 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI SALVATORE, JESSICA E · 2016 to 2020
$741k
NIAAA NIH HHS K01 AA024152NIAAA NIH HHS K02 AA018755NIAAA NIH HHS R01 AA012502NIAAA NIH HHS R01 AA015416
6 · The paper itself

Abstract

This review offers an update on research conducted with FinnTwin12 (FT12), the youngest of the three Finnish Twin Cohorts. FT12 was designed as a two-stage study. In the first stage, we conducted multiwave questionnaire research enrolling all eligible twins born in Finland during 1983-1987 along with their biological parents. In stage 2, we intensively studied a subset of these twins with in-school assessments at age 12 and semistructured poly-diagnostic interviews at age 14. At baseline, parents of intensively studied twins were administered the adult version of the interview. Laboratory studies with repeat interviews, neuropsychological tests, and collection of DNA were made of intensively studied twins during follow-up in early adulthood. The basic aim of the FT12 study design was to obtain information on individual, familial and school/neighborhood risks for substance use/abuse prior to the onset of regular tobacco and alcohol use and then track trajectories of use and abuse and their consequences into adulthood. But the longitudinal assessments were not narrowly limited to this basic aim, and with multiwave, multirater assessments from ages 11 to 12, the study has created a richly informative data set for analyses of gene-environment interactions of both candidate genes and genomewide measures with measured risk-relevant environments. Because 25 years have elapsed since the start of the study, we are planning a fifth-wave follow-up assessment.

Indexed as

Gene-Environment InteractionAdolescentAdultChildFemaleFinlandFollow-Up StudiesHumansMaleSubstance-Related DisordersTwinsalcoholdietdiverse phenotypesepigeneticsgeneticsLongitudinal twin-family studymental healthmetabolomicsphysical activitysmokingtwinstwo-stage design

Identifiers

PMID31640839
PMCPMC7108792
OpenAlexW2982011104

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.