Evidence map›Paper›PMID 31640785›Full record

ReviewJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale2019

A case report of severe nasal ischemia from cold agglutinin disease and a novel treatment protocol including HBOT.

Scott Kohlert, Laurie McLean, Dimitrios Scarvelis, Calvin Thompson

Open access · goldAbstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Systematic review of non-surgical etiologies of nasal necrosis: evidence from case reports and case series.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Pooled it
  2. [Cold agglutinin disease (CAD)].Innere Medizin (Heidelberg, Germany) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Scott KohlertENT Associates of East Texas, 1136 E Grande Blvd, Tyler, TX, USA. kohlert@me.com.ORCID http://orcid.org/0000-0003-1814-0776
Laurie McLeanDepartment of Otolaryngology - Head and Neck Surgery The Ottawa Hospital, University of Ottawa, 501 Smyth Rd, Ottawa, Ontario, K1H 8L6, Canada.
Dimitrios ScarvelisDepartment of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Calvin ThompsonCanada. Hyperbaric Medicine Unit The Ottawa Hospital, Ottawa, Ontario, Canada.
University of Ottawa · CATrinity Mother Frances Hospitals and Clinics · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cold agglutinin disease (CAD) is a rare condition leading to blood agglutination and autoimmune hemolytic anemia. Cutaneous ischemia resulting from CAD in the head and neck is uncommon. Treatment regimens and outcomes vary widely in the literature and no clear protocol exists. This manuscript describes a patient with CAD who developed severe ischemia of the nose that resolved completely without sequellae following a medical regimen of aspirin, low molecular weight heparin, nitroglycerin ointment and hyperbaric oxygen therapy (HBOT). To our knowledge, this is the first reported case where nitroglycerin ointment or HBOT was successfully employed in the treatment of this complication.

Indexed as

Hyperbaric OxygenationAdministration, TopicalAged, 80 and overAnemia, Hemolytic, AutoimmuneAnticoagulantsCombined Modality TherapyEnoxaparinFemaleHumansIschemiaNitroglycerinNoseOintmentsVasodilator AgentsAnticoagulantsEnoxaparinNitroglycerinOintmentsVasodilator AgentsAcrocyanosisCold agglutinin diseaseHyperbaric oxygenNasal ischemia

Identifiers

PMID31640785
PMCPMC6805523
OpenAlexW2981494960

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.