Evidence map›Paper›PMID 31640743›Full record

ArticleBMC complementary and alternative medicine2019

Glucose and lipid lowering effects of Enhydra fluctuans extract in cadmium treated normal and type-2 diabetic model rats.

Mohammad Nazmul Hasan, Farah Sabrin, Begum Rokeya, Md Shahinul Haque Khan, Mahtab Uddin Ahmed, Abel Matondo, Md Morsaline Billah, Salima Akter

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC complementary and alternative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 14 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Mohammad Nazmul HasanDepartment of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail, 1902, Bangladesh.
Farah SabrinDepartment of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail, 1902, Bangladesh.
Begum RokeyaDepartment of Pharmacology, Bangladesh University of Health Sciences, Dhaka, 1216, Bangladesh.
Md Shahinul Haque KhanDepartment of Chemistry, Bangladesh University of Health Sciences, Dhaka, 1216, Bangladesh.
Mahtab Uddin AhmedDepartment of Pathology, Bangladesh University of Health Sciences, Dhaka, 1216, Bangladesh.
Abel MatondoDepartment of Health and Social Care, St. Patrick's College, London, UK.
Md Morsaline BillahBiotechnology and Genetic Engineering Discipline, Khulna University, Khulna, 9208, Bangladesh.
Salima AkterDepartment of Medical Biotechnology, Bangladesh University of Health Sciences, Dhaka, 1216, Bangladesh. salima_2015@buhs.ac.bd.ORCID http://orcid.org/0000-0002-1769-5879
Bangladesh University of Health Sciences · BDMawlana Bhashani Science and Technology University · BDBangladesh University · BDDepartment of Health and Social Care · GBKhulna University · BD

Funding

Ministry of Science and Technology, Government of the People's Republic of Bangladesh 39.00.0000.09.02.69.16-17/BS-184/198
6 · The paper itself

Abstract

backgroundRecent epidemiological and experimental studies suggest that cadmium and diabetes-related hyperglycemia may act synergistically to worsen metabolic regulation. The present study aims to evaluate the potential effects of Enhydra fluctuans extract in diabetes and dyslipidemia in cadmium (CdCl

methodForty-eight Long-Evans rats were divided equally into the following six groups: Normal Control (N-C), Normal treated with CdCl

resultsTwenty-one days treatment of E. fluctuans extracts at a dose of 200 mg/kg significantly reduced blood glucose level in N-PCd and DM-PCd (p < 0.05), and DM-P (p < 0.01) group. The plant extract had no direct effects on total blood lipids but, it had beneficial effects on TG/HDL-C ratio in N-P and DM-PCd groups (p < 0.05). Cd induction significantly reduced body weight [(N-Cd, N-PCd, DM-PCd) (p < 0.01)], and induced liver [N-Cd (p < 0.05), N-PCd, p < 0.001] and renal impairment [N-Cd (p < 0.05)]. In bi-variate association, a significant positive correlation between serum glucose and SGPT (p < 0.05) as well as SGPT and TG/HDL ratio (p = 0.019) was found in DM-P and in the merged group. The histology of liver and heart showed severe damages including inflammation, nuclear pyknosis, loss of myocardial fibers, necrosis and fibrosis in the Cd treated groups compared to plant treated groups.

conclusionE. fluctuans seems to have potent antihyperglycemic effects in diabetes and Cd toxicity along with partial antidyslipidemic properties in euglycemic and diabetic rats. Our study suggests a novel oral antihyperglycemic agent in the present environmental context.

Indexed as

AnimalsAsteraceaeBlood GlucoseCadmiumDiabetes Mellitus, Type 2Disease Models, AnimalFemaleHumansHyperglycemiaHypoglycemic AgentsHypolipidemic AgentsLipid MetabolismLipidsMalePlant ExtractsRatsBlood GlucoseCadmiumHypoglycemic AgentsHypolipidemic AgentsLipidsPlant ExtractsCadmium toxicityDyslipidemiaEnhydra fluctuansHyperglycemiaType 2 diabetes

Identifiers

PMID31640743
PMCPMC6805336
OpenAlexW2981640792

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.