Evidence map›Paper›PMID 31640675›Full record

ArticleBMC endocrine disorders2019

A pitfall of bilateral inferior petrosal sinus sampling in cyclic Cushing's syndrome.

Adriana Albani, Christina M Berr, Felix Beuschlein, Marcus Treitl, Klaus Hallfeldt, Jürgen Honegger, Günter Schnauder, Martin Reincke

Open access · goldAbstract readCase Reports
In one paragraph

Article in BMC endocrine disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

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  12. Cyclic Cushing's Syndrome - A Diagnostic Challenge.Frontiers in endocrinology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Adriana AlbaniMedizinische Klinik und Poliklinik IV, Ludwig Maximilian University München, Ziemssenstr. 1, 80336, Munich, Germany.
Christina M BerrMedizinische Klinik und Poliklinik IV, Ludwig Maximilian University München, Ziemssenstr. 1, 80336, Munich, Germany.
Felix BeuschleinMedizinische Klinik und Poliklinik IV, Ludwig Maximilian University München, Ziemssenstr. 1, 80336, Munich, Germany.
Marcus TreitlKlinik und Poliklinik für Radiologie, Klinikum der Universität München, LMU München, Munich, Germany.
Klaus HallfeldtChirurgische Klinik und Poliklinik-Innenstadt Klinikum der Ludwig-Maximilians-Universität München, Munich, Germany.
Jürgen HoneggerDepartment of Neurosurgery, Eberhard Karls University Tubingen, Tubingen, Germany.
Günter SchnauderDepartment of Internal Medicine, Endocrinology and Diabetology, University of Tubingen, Tubingen, Germany.
Martin ReinckeMedizinische Klinik und Poliklinik IV, Ludwig Maximilian University München, Ziemssenstr. 1, 80336, Munich, Germany. Martin.Reincke@med.uni-muenchen.de.
Ludwig-Maximilians-Universität München · DEUniversity of Tübingen · DELMU Klinikum · DE

Funding

Deutsche Forschungsgemeinschaft CRC/Transregio 205/1Else Kröner-Fresenius-Stiftung 2012_A103Else Kröner-Fresenius-Stiftung 2015-A228
6 · The paper itself

Abstract

backgroundClinical care of patients with cyclic Cushing's syndrome (CS) is challenging. Classical pitfalls include incorrect subtyping, unnecessary surgical procedures and delayed definite treatment. CASE PRESENTATION: A 43-year-old female suffered from a rapidly cycling ectopic CS. She experienced six cycles of severe hypercortisolism within a 2 year period (maximum plasma cortisol 5316 nmol/L, normal range 124.2-662.4 nmol/L; maximum urinary free cortisol 79,469 nmol/24 h, normal range < 414 nmol/24 h) lasting 2-9 weeks. The episodes were associated with pronounced hypokalemia (lowest K

conclusionsWe report the challenging case of a rapidly cycling CS secondary to ACTH-secreting neuroendocrine intestinal tumor of unknown primary. We highlight the importance of performing diagnostic tests only during the phases of active cortisol secretion and as soon as first symptoms appear to avoid pitfalls.

Indexed as

AdultBiomarkersCarcinoma, NeuroendocrineCorticotropin-Releasing HormoneCushing SyndromeDiagnosis, DifferentialDiagnostic ErrorsFemaleHumansIntestinal NeoplasmsNeoplasms, Unknown PrimaryPetrosal Sinus SamplingPrognosisBiomarkersCorticotropin-Releasing HormoneACTHCortisolCushing diseaseHypercortisolismNeuroendocrine tumor

Identifiers

PMID31640675
PMCPMC6805379
OpenAlexW2981918533

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.