ArticleBMC infectious diseases2019
Molecular characteristics and virulence gene profiles of Staphylococcus aureus isolates in Hainan, China.
Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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55 citing papers in PubMed.
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- Genetic diversity, virulence factors and antimicrobial resistance profiles of S. aureus isolated from raw meat, meat products and veterinary samples of food-producing animals in South African provinces.BMC microbiology · 2026Article
- Prevalence and Characterization of Methicillin-ResistantFoods (Basel, Switzerland) · 2026Article
- Molecular characteristics and pathogenicity-associated phenotypes of methicillin-resistantFrontiers in public health · 2026Article
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- Molecular identification of antibiotic-resistant and virulentJournal of advanced veterinary and animal research · 2025Article
- Antibiotic susceptibility and molecular characterization based on whole-genome sequencing of Staphylococcus aureus causing invasive infection in children and women living in Southwest China during 2018-2023.BMC microbiology · 2025Article
- Surveillance of Antibiotic Resistance and Molecular Epidemiology ofInfection and drug resistance · 2025Article
- Small regulatory RNA RSaX28 promotes virulence by reinforcing the stability of RNAIII in community-associated ST398 clonotypeEmerging microbes & infections · 2024Article
- Molecular and Phylogenomic Analysis of a Vancomycin Intermediate Resistance USA300LV Strain in Chile.Microorganisms · 2024Article
- Molecular characterization and antibiotic resistance ofFood science and biotechnology · 2024Article
- Natural compounds in the fight againstFrontiers in pharmacology · 2024Review
- Whole-genome analysis of a ST45-SCCFrontiers in cellular and infection microbiology · 2024Article
- Genomic characterization and outbreak investigations of methicillin-resistantFrontiers in microbiology · 2024Article
- Genome Analysis of Methicillin-Resistant and Methicillin-SusceptibleMicroorganisms · 2023Article
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Abstract
backgroundThere have been no reports regarding the molecular characteristics, virulence features, and antibiotic resistance profiles of Staphylococcus aureus (S. aureus) from Hainan, the southernmost province of China.
methodsTwo hundred twenty-seven S. aureus isolates, consisting of 76 methicillin-resistant S. aureus (MRSA) and 151 methicillin-susceptible S. aureus (MSSA), were collected in 2013-2014 and 2018-2019 in Hainan, and investigated for their molecular characteristics, virulence genes, antibiotic resistance profiles and main antibiotic resistance genes.
resultsForty sequence types (STs) including three new STs (ST5489, ST5492 and ST5493), and 79 Staphylococcal protein A (spa) types were identified based on multilocus sequence typing (MLST) and spa typing, respectively. ST398 (14.1%, 32/227) was found to be the most prevalent, and the prevalence of ST398-MSSA increased significantly from 2013 to 2014 (5.5%, 5/91) to 2018-2019 (18.4%, 25/136). Seventy-six MRSA isolates were subject to staphylococcus chromosomal cassette mec (SCCmec) typing. SCCmec-IVa was the predominant SCCmec type, and specifically, ST45-SCCmec IVa, an infrequent type in mainland China, was predominant in S. aureus from Hainan. The antibiotic resistance profiles and antibiotic resistance genes of S. aureus show distinctive features in Hainan. The resistant rates of the MRSA isolates to a variety of antibiotics were significantly higher than those of the MSSA isolates. The predominant erythromycin and tetracycline resistance genes were ermC (90.1%, 100/111) and tetK (91.8%, 78/85), respectively. Eleven virulence genes, including the Panton-Valentine leukocidin (pvl) and eta, were determined, and the frequency of eta and pvl were found to be 57.3 and 47.6%. Such high prevalence has never been seen in mainland China before.
conclusionS. aureus isolates in Hainan have unique molecular characteristics, virulence gene and antibiotic resistance profiles, and main antibiotic resistance genes which may be associated with the special geographical location of Hainan and local trends in antibiotic use.
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