ArticleBMC genomics2019
Identification of genomic regions regulating sex determination in Atlantic salmon using high density SNP data.
Article in BMC genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 27 citations in OpenAlex.
- Intergenic Variants Upstream of GADD45b Affect Survival ofInternational journal of molecular sciences · 2025Article
- Genome-wide association study reveals genomic loci of sex differentiation and gonadal development inFrontiers in genetics · 2023Article
- Whole-Genome Inter-Sex Variation in Russian Sturgeon (International journal of molecular sciences · 2022Article
- Detecting Local Adaptation between North and South European Atlantic Salmon Populations.Biology · 2022Article
- Something Fishy about Siamese Fighting Fish (Cells · 2022Article
- Lessons from an unusual vertebrate sex-determining gene.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- The pink salmon genome: Uncovering the genomic consequences of a two-year life cycle.PloS one · 2021Article
- AutosomalFrontiers in genetics · 2020Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA complete understanding of the genetic basis for sexual determination and differentiation is necessary in order to implement efficient breeding schemes at early stages of development. Atlantic salmon belongs to the family Salmonidae of fishes and represents a species of great commercial value. Although the species is assumed to be male heterogametic with XY sex determination, the precise genetic basis of sexual development remains unclear. The complexity is likely associated to the relatively recent salmonid specific whole genome duplication that may be responsible for certain genome instability. This instability together with the capacity of the sex-determining gene to move across the genome as reported by previous studies, may explain that sexual development genes are not circumscribed to the same chromosomes in all members of the species. In this study, we have used a 220 K SNP panel developed for Atlantic salmon to identify the chromosomes explaining the highest proportion of the genetic variance for sex as well as candidate regions and genes associated to sexual development in this species.
resultsResults from regional heritability analysis showed that the chromosomes explaining the highest proportion of variance in these populations were Ssa02 (heritability = 0.42, SE = 0.12) and Ssa21 (heritability = 0.26, SE = 0.11). After pruning by linkage disequilibrium, genome-wide association analyses revealed 114 SNPs that were significantly associated with sex, being Ssa02 the chromosome containing a greatest number of regions. Close examination of the candidate regions evidenced important genes related to sex in other species of Class Actinopterygii, including SDY, genes from family SOX, RSPO1, ESR1, U2AF2A, LMO7, GNRH-R, DND and FIGLA.
conclusionsThe combined results from regional heritability analysis and genome-wide association have provided new advances in the knowledge of the genetic regulation of sex determination in Atlantic salmon, supporting that Ssa02 is the candidate chromosome for sex in this species and suggesting an alternative population lineage in Spanish wild populations according to the results from Ssa21.
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