ReviewOpen biology2019
Cellular sensing of micron-scale curvature: a frontier in understanding the microenvironment.
Review in Open biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Geometrical Designs in Volumetric Bioprinting to Study Cellular Behaviors in Engineered Constructs.Advanced healthcare materials · 2026Article
- Practical Guide to the Design of Granular Hydrogels for Customizing Complex Cellular Microenvironments.Advanced healthcare materials · 2025Review
- A minimal physical model for curvotaxis driven by curved protein complexes at the cell's leading edge.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Helical vasculogenesis driven by cell chirality.Science advances · 2024Article
- Integrating mechanical cues with engineered platforms to explore cardiopulmonary development and disease.iScience · 2023Review
- Effect of Porous Substrate Topographies on Cell Dynamics: A Computational Study.ACS biomaterials science & engineering · 2023Article
- Experimental and theoretical model for the origin of coiling of cellular protrusions around fibers.Nature communications · 2023Article
- Stiffness Restricts the Stemness of the Intestinal Stem Cells and Skews Their Differentiation Toward Goblet Cells.Gastroenterology · 2023Article
- Printing channels with millimeter-scale curvature and deciphering their effect on the proliferation, morphology, orientation, and migration of M-22 cells.International journal of bioprinting · 2023Article
- Image-based crosstalk analysis of cell-cell interactions during sprouting angiogenesis using blood-vessel-on-a-chip.Stem cell research & therapy · 2022Article
- 3D Lung-on-Chip Model Based on Biomimetically Microcurved Culture Membranes.ACS biomaterials science & engineering · 2022Article
- Myofibroblast transdifferentiation of keratocytes results in slower migration and lower sensitivity to mesoscale curvatures.Frontiers in cell and developmental biology · 2022Article
- Recent advances in biofabricated gut models to understand the gut-brain axis in neurological diseases.Frontiers in medical technology · 2022Review
- Protein Micropatterning in 2.5D: An Approach to Investigate Cellular Responses in Multi-Cue Environments.ACS applied materials & interfaces · 2021Article
- Microtissue Geometry and Cell-Generated Forces Drive Patterning of Liver Progenitor Cell Differentiation in 3D.Advanced healthcare materials · 2021Article
- Emergent Differential Organization of Airway Smooth Muscle Cells on Concave and Convex Tubular Surface.Frontiers in molecular biosciences · 2021Article
- Bioinstructive Micro-Nanotextured Zirconia Ceramic Interfaces for Guiding and Stimulating an Osteogenic Response In Vitro.Nanomaterials (Basel, Switzerland) · 2020Article
- Air-pressure-driven Separable Microdevice to Control the Anisotropic Curvature of Cell Culture Surface.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2020Article
- Review
- Imaging the Cell Morphological Response to 3D Topography and Curvature in Engineered Intestinal Tissues.Frontiers in bioengineering and biotechnology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The vast majority of cell biological studies examine function and molecular mechanisms using cells on flat surfaces: glass, plastic and more recently elastomeric polymers. While these studies have provided a wealth of valuable insight, they fail to consider that most biologically occurring surfaces are curved, with a radius of curvature roughly corresponding to the length scale of cells themselves. Here, we review recent studies showing that cells detect and respond to these curvature cues by adjusting and re-orienting their cell bodies, actin fibres and nuclei as well as by changing their transcriptional programme. Modelling substratum curvature has the potential to provide fundamental new insight into cell behaviour and function
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.