ArticleAnalytical chemistry2019
Super-Resolution Reconstruction for Two- and Three-Dimensional LA-ICP-MS Bioimaging.
Article in Analytical chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 39 citations in OpenAlex.
- Computational Mass Spectrometry Imaging in the Era of AI.Chemical reviews · 2026Review
- Multimodal FRACTAL-MSI and Image Fusion Improves Detection and Resolution of Biomolecule Imaging.ACS central science · 2026Article
- TyrRu: A Tyramide-Amplified Multimodal Ruthenium Tag for Elemental Mass Spectrometry and Immunofluorescence Imaging.Chemical & biomedical imaging · 2026Article
- Ion Beam Imaging Shows Selective Thallium-201 Uptake in Cell Nuclei: Impact on Cellular Dosimetry and Radiotoxicity of Auger Electron Emitters.Chemical & biomedical imaging · 2026Article
- A Correlative X‑ray Bioimaging Triad for Metals in Biomedical Research.Chemical & biomedical imaging · 2026Review
- Advances in Mammalian Metallomics: New Insights into Metal Dynamics and Biological Significance.International journal of molecular sciences · 2025Review
- Exploring the Benefits of Ablation Grid Adaptation in 2D/3D Laser Ablation Inductively Coupled Plasma Mass Spectrometry Mapping through Geometrical Modeling.Analytical chemistry · 2023Article
- Assessing the reproducibility of labelled antibody binding in quantitative multiplexed immuno-mass spectrometry imaging.Analytical and bioanalytical chemistry · 2021Article
- Quantitative Mass Spectrometry Imaging of Biological Systems.Annual review of physical chemistry · 2021Review
- Effective processing and evaluation of chemical imaging data with respect to morphological features of the zebrafish embryo.Analytical and bioanalytical chemistry · 2021Article
- Quantitative immuno-mass spectrometry imaging of skeletal muscle dystrophin.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The resolution of laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) elemental bioimaging is usually constrained by the diameter of the laser spot size and is often not adequate to explore in situ subcellular distributions of elements and proteins in biological tissue sections. Super-resolution reconstruction is a method typically used for many imaging modalities and combines multiple lower resolution images to create a higher resolution image. Here, we present a super-resolution reconstruction method for LA-ICP-MS imaging by ablating consecutive layers of a biological specimen with offset orthogonal scans, resulting in a 10× improvement in resolution for quantitative measurement of dystrophin in murine muscle fibers. Layer-by-layer image reconstruction was also extended to the third dimension without the requirement of image registration across multiple thin section specimens. Quantitative super-resolution reconstruction, combined with Gaussian filtering and application of the Richardson-Lucy total variation algorithm, provided superior image clarity and fidelity in two- and three-dimensions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.