Evidence map›Paper›PMID 31640215›Full record

ArticleNutrients2019

Meat Proteins as Dipeptidyl Peptidase IV Inhibitors and Glucose Uptake Stimulating Peptides for the Management of a Type 2 Diabetes Mellitus In Silico Study.

Paulina Kęska, Joanna Stadnik, Olga Bąk, Piotr Borowski

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 27 citations in OpenAlex.

  1. Trial
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Paulina KęskaDepartment of Animal Raw Materials Technology, Faculty of Food Science and Biotechnology, University of Life Sciences in Lublin, Skromna 8, 20-704 Lublin, Poland. paulina.keska@up.lublin.pl.
Joanna StadnikDepartment of Animal Raw Materials Technology, Faculty of Food Science and Biotechnology, University of Life Sciences in Lublin, Skromna 8, 20-704 Lublin, Poland. joanna.stadnik@up.lublin.pl.ORCID 0000-0002-5029-5535
Olga BąkFaculty of Chemistry, Marie Curie-Sklodowska University in Lublin, 3 Marie Curie-Sklodowska Sq., 20-031 Lublin, Poland. olga.bak@poczta.umcs.lublin.pl.
Piotr BorowskiFaculty of Chemistry, Marie Curie-Sklodowska University in Lublin, 3 Marie Curie-Sklodowska Sq., 20-031 Lublin, Poland. piotr.borowski@poczta.umcs.lublin.pl.
Maria Curie-Skłodowska University · PLUniversity of Life Sciences in Lublin · PL

Funding

The research was funded by the National Science Centre, Poland (Research Grant No.2018/29/N/NZ9/01965)
6 · The paper itself

Abstract

Diabetes mellitus is a non-communicable disease entity currently constituting one of the most significant health problems. The development of effective therapeutic strategies for the prevention and/or treatment of diabetes mellitus based on the selection of methods to restore and maintain blood glucose homeostasis is still in progress. Among the different courses of action, inhibition of dipeptidyl peptidase IV (DPP-IV) can improve blood glucose control in diabetic patients. Pharmacological therapy offering synthetic drugs is commonly used. In addition to medication, dietary intervention may be effective in combating metabolic disturbances caused by diabetes mellitus. Food proteins as a source of biologically active sequences are a potential source of anti-diabetic peptides (DPP-IV inhibitors and glucose uptake stimulating peptides). This study showed that in silico pork meat proteins digested with gastrointestinal enzymes are a potential source of bioactive peptides with a high potential to control blood glucose levels in patients with type 2 diabetes mellitus. Analysis revealed that the sequences released during in silico digestion were small dipeptides (with an average weight of 270.07 g mol

Indexed as

Computer SimulationHypoglycemic AgentsAnimalsBlood GlucoseChemical PhenomenaChymotrypsinDiabetes Mellitus, Type 2DipeptidesDipeptidyl-Peptidase IV InhibitorsGlucoseHumansMeat ProteinsPepsin ASus scrofaTrypsinBlood GlucoseChymotrypsinDipeptidesDipeptidyl-Peptidase IV InhibitorsGlucoseHypoglycemic AgentsMeat ProteinsPepsin ATrypsinbioactive peptidesDPP-IV inhibitorsin silicopork proteins

Identifiers

PMID31640215
PMCPMC6836043
OpenAlexW2980808764

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.