ArticleMicromachines2019
Single and Multi-Objective Optimization of a Three-Dimensional Unbalanced Split-and-Recombine Micromixer.
Article in Micromachines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- A Review on Micromixers, Microdroplet Generators and Their Integration.Micromachines · 2026Review
- Enhancement of Mixing Performance of Two-Layer Crossing Micromixer through Surrogate-Based Optimization.Micromachines · 2021Article
- Surface Response Based Modeling of Liposome Characteristics in a Periodic Disturbance Mixer.Micromachines · 2020Article
- Mixing Optimization in Grooved Serpentine Microchannels.Micromachines · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The three-dimensional geometry of a micromixer with an asymmetrical split-and-recombine mechanism was optimized to enhance the fluid-mixing capability at a Reynolds number of 20. Single and multi-objective optimizations were carried out by using particle swarm optimization and a genetic algorithm on a modeled surrogate surface. Surrogate modeling was performed using the computational results for the mixing. Mixing and flow analyses were carried out by solving the convection-diffusion equation in combination with the three-dimensional continuity and momentum equations. The optimization was carried out with two design variables related to dimensionless geometric parameters. The mixing effectiveness was chosen as the objective function for the single-objective optimization, and the pressure drop and mixing index at the outlet were chosen for the multi-objective optimization. The sampling points in the design space were determined using a design of experiment technique called Latin hypercube sampling. The surrogates for the objective functions were developed using a Kriging model. The single-objective optimization resulted in 58.9% enhancement of the mixing effectiveness compared to the reference design. The multi-objective optimization provided Pareto-optimal solutions that showed a maximum increase of 48.5% in the mixing index and a maximum decrease of 55.0% in the pressure drop in comparison to the reference design.
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Registered trials
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