Observational studyJournal of Alzheimer's disease : JAD2019
Midlife Psychological Well-Being and its Impact on Cognitive Functioning Later in Life: An Observational Study Using a Female British Birth Cohort.
Observational study in Journal of Alzheimer's disease : JAD, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Do all components of psychological well-being predict cognitive function?The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- Associations between life satisfaction and hope with cognitive function and decline over 13 years: findings from the Whitehall II study.European journal of ageing · 2025Article
- Bidirectional association between depression and cognition in Chinese middle-aged and older women: a 10-year longitudinal study.Frontiers in psychiatry · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundThere is growing interest in public health strategies to modify dementia risk in midlife to reduce the burden of cognitive impairment in subsequent decades. Risk reduction messages should include key recommendations for women in response to the high prevalence of dementia observed in this population. Midlife is a critical period for dementia-related brain changes and psychosocial crises. Psychological well-being can improve resilience to crises, yet it is not well understood with respect to dementia risk reduction.
objectiveThis study aimed to examine the association between midlife psychological well-being and cognitive function in later life in women.
methodsThe study included 703 women from the British 1946 birth cohort in the Medical Research Council's National Survey of Health and Development. Psychological well-being at 52 years was assessed using the Ryff Scales of Psychological Well-being over six dimensions: autonomy, environmental mastery, personal growth, positive relations with others, purpose in life, and self-acceptance. Cognitive function at 69 years was measured using the Addenbrooke's Cognitive Examination, Third Edition.
resultsAfter controlling for cognitive ability at eight years, educational attainment by 26 years, occupational attainment and marital status by 53 years, depression, smoking, and physical exercise at 60-64 years, there was a significant association between greater personal growth and lower self-acceptance at 52 years, and better cognition at 69 years. However, there was no association between cognition and the other four Ryff scales.
conclusionMost aspects of midlife psychological well-being, except for personal growth and self-acceptance, were not prospectively associated with cognition.
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