ArticleNeuroImage2020
Interhemispheric transfer of post-amputation cortical plasticity within the human somatosensory cortex.
Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Cutting a nerve of the hand alters the organization of digit maps in primary somatosensory cortex.Nature human behaviour · 2026Article
- Post-Critical Period Transcriptional and Physiological Adaptations of Primary Sensory Cortex after Sensory Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Recent progress in chronic pain-related negative emotions and cognitive dysfunction: insights into the mechanisms underlying neural circuitry.Frontiers in cellular neuroscience · 2026Review
- Transient synaptic refinement and glial adaptations after whisker denervation in adult mice.Frontiers in cellular neuroscience · 2026Article
- Brain activation for actual and imagined hand movement following bilateral hand transplantation.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- A neural substrate for sensory over-responsivity defined by exogenous and endogenous brain systems.Journal of neurodevelopmental disorders · 2025Article
- Stable cortical body maps before and after arm amputation.Nature neuroscience · 2025Article
- Pain without presence: a narrative review of the pathophysiological landscape of phantom limb pain.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- Changes in Functional and Structural Brain Connectivity Following Bilateral Hand Transplantation.Neuroimage. Reports · 2024Article
- The neurophysiology of sensorimotor prosthetic control.BMC biomedical engineering · 2024Review
- Does Ipsilateral Remapping Following Hand Loss Impact Motor Control of the Intact Hand?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Cortical Reorganization after Limb Loss: Bridging the Gap between Basic Science and Clinical Recovery.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Against cortical reorganisation.eLife · 2023Article
- Reassessing referral of touch following peripheral deafferentation: The role of contextual bias.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Article
- Similar somatotopy for active and passive digit representation in primary somatosensory cortex.Human brain mapping · 2023Article
- Stimulation of peroneal nerves reveals maintained somatosensory representation in transtibial amputees.Frontiers in human neuroscience · 2023Article
- Complex pattern of facial remapping in somatosensory cortex following congenital but not acquired hand loss.eLife · 2022Article
- Transfer of Tactile Learning from Trained to Untrained Body Parts Supported by Cortical Coactivation in Primary Somatosensory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Peripheral Nerve Injury Induces Changes in the Activity of Inhibitory Interneurons as Visualized in Transgenic GAD1-GCaMP6s Rats.Biosensors · 2022Article
- Changes in Primary Somatosensory Cortex Following Allogeneic Hand Transplantation or Autogenic Hand Replantation.Frontiers in neuroimaging · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Animal models reveal that deafferenting forelimb injuries precipitate reorganization in both contralateral and ipsilateral somatosensory cortices. The functional significance and duration of these effects are unknown, and it is unclear whether they also occur in injured humans. We delivered cutaneous stimulation during functional magnetic resonance imaging (fMRI) to map the sensory cortical representation of the intact hand and lower face in a group of chronic, unilateral, upper extremity amputees (N = 19) and healthy matched controls (N = 29). Amputees exhibited greater activity than controls within the deafferented former sensory hand territory (S1f) during stimulation of the intact hand, but not of the lower face. Despite this cortical reorganization, amputees did not differ from controls in tactile acuity on their intact hands. S1f responses during hand stimulation were unrelated to tactile acuity, pain, prosthesis usage, or time since amputation. These effects appeared specific to the deafferented somatosensory modality, as fMRI visual mapping paradigm failed to detect any differences between groups. We conclude that S1f becomes responsive to cutaneous stimulation of the intact hand of amputees, and that this modality-specific reorganizational change persists for many years, if not indefinitely. The functional relevance of these changes, if any, remains unknown.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.