Evidence map›Paper›PMID 31639389›Full record

ArticleJournal of molecular and cellular cardiology2019

Metabolic regulation of Kv channels and cardiac repolarization by Kvβ2 subunits.

Peter J Kilfoil, Kalyan C Chapalamadugu, Xuemei Hu, Deqing Zhang, Frank J Raucci, Jared Tur, Kenneth R Brittian, Steven P Jones, Aruni Bhatnagar, Srinivas M Tipparaju and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of molecular and cellular cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. KFrontiers in pharmacology · 2026
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. The role of lactate in cardiovascular diseases.Cell communication and signaling : CCS · 2023
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. NADMolecular and cellular biochemistry · 2022
    Review
  17. Collagen type XIX regulates cardiac extracellular matrix structure and ventricular function.Matrix biology : journal of the International Society for Matrix Biology · 2022
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Peter J KilfoilDepartment of Medicine, Christina Lee Brown Envirome Institute, and Diabetes and Obesity Center, University of Louisville, Louisville, KY, United States of America.
Kalyan C ChapalamaduguDepartment of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, FL, United States of America.
Xuemei HuDepartment of Medicine, Christina Lee Brown Envirome Institute, and Diabetes and Obesity Center, University of Louisville, Louisville, KY, United States of America.
Deqing ZhangDepartment of Medicine, Christina Lee Brown Envirome Institute, and Diabetes and Obesity Center, University of Louisville, Louisville, KY, United States of America.
Frank J RaucciDepartment of Medicine, Christina Lee Brown Envirome Institute, and Diabetes and Obesity Center, University of Louisville, Louisville, KY, United States of America.
Jared TurDepartment of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, FL, United States of America.
Kenneth R BrittianDepartment of Medicine, Christina Lee Brown Envirome Institute, and Diabetes and Obesity Center, University of Louisville, Louisville, KY, United States of America.
Steven P JonesDepartment of Medicine, Christina Lee Brown Envirome Institute, and Diabetes and Obesity Center, University of Louisville, Louisville, KY, United States of America.
Aruni BhatnagarDepartment of Medicine, Christina Lee Brown Envirome Institute, and Diabetes and Obesity Center, University of Louisville, Louisville, KY, United States of America.
Srinivas M TipparajuDepartment of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, FL, United States of America. Electronic address: stippara@usf.edu.
Matthew A NystoriakDepartment of Medicine, Christina Lee Brown Envirome Institute, and Diabetes and Obesity Center, University of Louisville, Louisville, KY, United States of America. Electronic address: matthew.nystoriak@louisville.edu.
University of Louisville · USUniversity of South Florida · US

Funding

Tumor Necrosis Factor Modulation of CPCsP01HL078825 · NHLBI · UNIVERSITY OF LOUISVILLE · PI BOLLI, ROBERTO · 2005 to 2021
$37.6M
Project 5 - Metabolomic Analysis of AtherothrombosisP20GM103492 · NIGMS · UNIVERSITY OF LOUISVILLE · PI HONG, KYUNG UK · 2012 to 2017
$13.8M
TBDP30GM127607 · NIGMS · UNIVERSITY OF LOUISVILLE · PI BHATNAGAR, ARUNI · 2018 to 2022
$6.3M
Regulation of Coronary Blood FlowR01HL142710 · NHLBI · UNIVERSITY OF LOUISVILLE · PI NYSTORIAK, MATTHEW A · 2018 to 2022
$3.1M
Regulation of Metabolic Genes in the HeartR01HL131647 · NHLBI · UNIVERSITY OF LOUISVILLE · PI JONES, STEVEN P · 2016 to 2019
$2.2M
Redox Regulation of Kv ChannelsR01HL102171 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI TIPPARAJU, SRINIVAS M. · 2011 to 2015
$1.6M
NHLBI NIH HHS P01 HL078825NHLBI NIH HHS R01 HL102171NHLBI NIH HHS R01 HL131647NHLBI NIH HHS R01 HL142710NIGMS NIH HHS P20 GM103492NIGMS NIH HHS P30 GM127607
6 · The paper itself

Abstract

Voltage-gated potassium (Kv) channels control myocardial repolarization. Pore-forming Kvα proteins associate with intracellular Kvβ subunits, which bind pyridine nucleotides with high affinity and differentially regulate channel trafficking, plasmalemmal localization and gating properties. Nevertheless, it is unclear how Kvβ subunits regulate myocardial K

Indexed as

Ion Channel GatingAction PotentialsAnimalsHeart Function TestsLactic AcidMiceMice, Inbred C57BLMyocardiumMyocytes, CardiacNucleotidesOxidation-ReductionProtein SubunitsPyridinesShaker Superfamily of Potassium ChannelsShal Potassium ChannelsKcnab2 protein, mouseLactic AcidNucleotidesProtein SubunitspyridinePyridinesShaker Superfamily of Potassium ChannelsShal Potassium ChannelsArrhythmiaHeartMetabolismNADRedox

Identifiers

PMID31639389
PMCPMC7344177
OpenAlexW2980950771

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.