Evidence map›Paper›PMID 31639388›Full record

ArticleJournal of molecular and cellular cardiology2019

Sam68 impedes the recovery of arterial injury by augmenting inflammatory response.

Shuling Han, Shiyue Xu, Junlan Zhou, Aijun Qiao, Chan Boriboun, Wenxia Ma, Huadong Li, Dauren Biyashev, Liu Yang, Eric Zhang and 9 more

RetractedOpen access · greenAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Role of Sam68 as an adaptor protein in inflammatory signaling.Cellular and molecular life sciences : CMLS · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Cell transplantation
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 3 countries.

Shuling HanFeinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Shiyue XuMolecular Cardiology Program, Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Junlan ZhouFeinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Aijun QiaoMolecular Cardiology Program, Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Chan BoribounMolecular Cardiology Program, Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Wenxia MaMolecular Cardiology Program, Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Huadong LiMolecular Cardiology Program, Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Dauren BiyashevFeinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Liu YangMolecular Cardiology Program, Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Eric ZhangMolecular Cardiology Program, Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Qinghua LiuInstitute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities, Wuhan 430074, Hubei, China.
Shayi JiangDepartment of Hematology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai 20062, China.
Ting C ZhaoDepartment of Surgery, Roger Williams Medical Center, Boston University Medical School, Providence, RI 02908, USA.
Prasanna KrishnamurthyMolecular Cardiology Program, Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Chunxiang ZhangMolecular Cardiology Program, Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Stéphane RichardLady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada.
Hongyu QiuCenter of Molecular and Translational Medicine, Institution of Biomedical Science, Georgia State University, Atlanta, GA 30303, USA.
Jianyi ZhangMolecular Cardiology Program, Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Gangjian QinFeinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Molecular Cardiology Program, Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: gqin@uab.edu.
University of Alabama at Birmingham · USNorthwestern University · USGeorgia State University · USMcGill University · CARoger Williams Medical Center · USShanghai Jiao Tong University · CNSouth Central Minzu University · CN

Funding

Endogenous and exogenous mechanisms that promote myocardial remuscularization in post infarction LV remodelingR01HL114120 · NHLBI · UNIVERSITY OF MINNESOTA · PI ZHANG, JIANYI · 2012 to 2021
$5.6M
Role of VCP in coronary ischemic injuryR01HL142291 · NHLBI · LOMA LINDA UNIVERSITY · PI QIU, HONGYU, XIE, ZHONGLIN · 2018 to 2021
$2.6M
E2F2 and Vascular FunctionR01HL138990 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI NAKADA, YUJI · 2017 to 2020
$2.3M
CXCR4 and ckit signaling in BM progenitor cell recruitment in the ischemic heartR01HL113541 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI QIN, GANGJIAN · 2012 to 2015
$1.5M
E2F1 in Cardiac NeovascularizationR01HL093439 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI QIN, GANGJIAN · 2010 to 2013
$1.5M
E2F1 in BM progenitor cell differentiation and cardiovascular repairR01HL131110 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI QIN, GANGJIAN, ZHAO, MING · 2016 to 2019
$1.5M
Novel mechanism mediating cardiac protection upon pressure overloadR01HL137962 · NHLBI · LOMA LINDA UNIVERSITY · PI QIU, HONGYU · 2018 to 2020
$1.2M
Novel mechanisms mediating cardiac protection upon pressure overloadR56HL137962 · NHLBI · LOMA LINDA UNIVERSITY · PI QIU, HONGYU · 2017 to 2017
$393k
NHLBI NIH HHS R01 HL093439NHLBI NIH HHS R01 HL113541NHLBI NIH HHS R01 HL114120NHLBI NIH HHS R01 HL131110NHLBI NIH HHS R01 HL137962NHLBI NIH HHS R01 HL138990NHLBI NIH HHS R01 HL142291NHLBI NIH HHS R56 HL137962
6 · The paper itself

Abstract

objectiveThe role of Src-associated-in-mitosis-68-kDa (Sam68) in cardiovascular biology has not been studied. A recent report suggests that Sam68 promotes TNF-α-induced NF-κB activation in fibroblasts. Here we sought to dissect the molecular mechanism by which Sam68 regulates NF-κB signaling and its functional significance in vascular injury. APPROACH AND

resultsThe endothelial denudation injury was induced in the carotid artery of Sam68-null (Sam68

conclusionsSam68 promotes pro-inflammatory response in injured arteries and impedes recovery by interacting with FLNA to stabilize TRAF2 on the cytoskeleton and consequently potentiate NF-κB signaling.

Indexed as

Adaptor Proteins, Signal TransducingAnimalsCarotid ArteriesCytokinesEndothelium, VascularFilaminsGene DeletionHyperplasiaInflammationInflammation MediatorsMacrophagesMaleMiceMice, Inbred C57BLNeointimaNF-kappa BAdaptor Proteins, Signal TransducingCytokinesFilaminsInflammation MediatorsKhdrbs1 protein, mouseNF-kappa BRNA-Binding ProteinsRNA, MessengerTumor Necrosis Factor-alphaFilamin aInflammationMacrophageNF-κBRestenosisSam68TNF-α

Identifiers

PMID31639388
PMCPMC6889069
OpenAlexW2980639416

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.