ArticleDevelopmental biology2020
Effector gene expression underlying neuron subtype-specific traits in the Motor Ganglion of Ciona.
Article in Developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Similarities betweeneNeuro · 2026Article
- Embodied postural dynamics underlie behavioral diversity in a benthic sessile chordate.iScience · 2026Article
- A protocadherin mediates oral placode morphogenesis in the tunicate Ciona.Biology open · 2026Article
- An NKX2-5 homolog is required downstream of BMP signaling to pattern the sensory-adhesive organ of a tunicate larva.bioRxiv : the preprint server for biology · 2025Article
- A gene regulatory network for specification and morphogenesis of a Mauthner Cell homolog in non-vertebrate chordates.Developmental biology · 2025Article
- Motor neurons in the tunicate caudal central nervous system reveal homology to the vertebrate spinal cord.Development (Cambridge, England) · 2025Article
- Development and circuitry of the tunicate larval Motor Ganglion, a putative hindbrain/spinal cord homolog.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024Review
- Loss of collagen gene expression in the notochord of the tailless tunicate Molgula occulta.Integrative and comparative biology · 2023Article
- Transitions of motor neuron activities duringFrontiers in cell and developmental biology · 2023Article
- Two distinct evolutionary conserved neural degeneration pathways characterized in a colonial chordate.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A single motor neuron determines the rhythm of early motor behavior inScience advances · 2021Article
- Disruption of left-right axis specification in Ciona induces molecular, cellular, and functional defects in asymmetric brain structures.BMC biology · 2021Article
- Neuromesodermal Lineage Contribution to CNS Development in Invertebrate and Vertebrate Chordates.Genes · 2021Review
- Regulation of Neurogenesis by FGF Signaling and Neurogenin in the Invertebrate ChordateFrontiers in cell and developmental biology · 2020Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
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Abstract
The central nervous system of the Ciona larva contains only 177 neurons. The precise regulation of neuron subtype-specific morphogenesis and differentiation observed during the formation of this minimal connectome offers a unique opportunity to dissect gene regulatory networks underlying chordate neurodevelopment. Here we compare the transcriptomes of two very distinct neuron types in the hindbrain/spinal cord homolog of Ciona, the Motor Ganglion (MG): the Descending decussating neuron (ddN, proposed homolog of Mauthner Cells in vertebrates) and the MG Interneuron 2 (MGIN2). Both types are invariantly represented by a single bilaterally symmetric left/right pair of cells in every larva. Supernumerary ddNs and MGIN2s were generated in synchronized embryos and isolated by fluorescence-activated cell sorting for transcriptome profiling. Differential gene expression analysis revealed ddN- and MGIN2-specific enrichment of a wide range of genes, including many encoding potential "effectors" of subtype-specific morphological and functional traits. More specifically, we identified the upregulation of centrosome-associated, microtubule-stabilizing/bundling proteins and extracellular guidance cues part of a single intrinsic regulatory program that might underlie the unique polarization of the ddNs, the only descending MG neurons that cross the midline. Consistent with our predictions, CRISPR/Cas9-mediated, tissue-specific elimination of two such candidate effectors, Efcab6-related and Netrin1, impaired ddN polarized axon outgrowth across the midline.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.