ArticleDiagnostic cytopathology2020
Cervical cytology reproducibility and associated clinical and demographic factors.
Article in Diagnostic cytopathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Hyperspectral Imaging of Whole-Cell Region for Differentiating Cervical Squamous Intraepithelial Lesion Cytology.Cancer medicine · 2026Article
- Impact of HIV infection on cervical intraepithelial neoplasia detection in pregnant and non-pregnant women in Germany: a cross-sectional study.Archives of gynecology and obstetrics · 2024Article
- Validation of AI-assisted ThinPrep® Pap test screening using the GeniusJournal of pathology informatics · 2024Article
- MUC1 promotes cervical squamous cell carcinoma through ERK phosphorylation-mediated regulation of ITGA2/ITGA3.BMC cancer · 2024Article
- Detection of cervical precancerous lesions and cancer by small-scale RT-qPCR analysis of oppositely deregulated mRNAs pairs in cytological smears.Frontiers in oncology · 2024Article
- Diagnostic Accuracy of p16Analytical cellular pathology (Amsterdam) · 2023Article
- Diagnostic Accuracy and Agreement Between Inter- and Intra-Observers in the Absence of Clinical History for Liquid-Based Preparation of Gynecology Specimens.Journal of cytologyArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundAlthough the Pap test has been the standard screening method for cervical precancer/cancer detection, it has been criticized for having a relatively low sensitivity and a low reproducibility between pathologists. There is limited knowledge about inter-rater agreement and what clinical and demographic factors are associated with disagreements between pathologists reading the same Pap smear.
methodsThis study aimed to assess inter- and intra- rater agreement of the Pap smear in 1619 cytologic slides with biopsy confirmation, using kappa statistics. Clinical and demographic factors associated with higher odds of inter-rater agreement were also examined and stratified by histologic diagnosis grade.
resultsUsing a five grade classification system, the overall kappa statistics for total, inter-rater, and intra-rater samples were 0.62, 0.57, and 0.88 (unweighted) and 0.83, 0.81, and 0.95 (weighted), respectively. In stratified analyses by histologic grade, total kappas ranged from 0.40 (atypia) to 0.64 (human papilloma virus/CIN 1). Factors such as referral for abnormal Pap test (diagnostic vs screening population), recruiting site, and parity were found to be associated with higher agreement between the two cytologic readings.
conclusionsWe observed relatively higher levels of agreement compared with other studies. However, variability was considerable and agreement was generally moderate, suggesting that cervical screening test accuracy and reproducibility needs to be improved.
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