ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2020
Education as a Moderator of the Relationship Between Episodic Memory and Amyloid Load in Normal Aging.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 25 citations in OpenAlex.
- Neuropathological and sociodemographic factors associated with the cortical amyloid load in aging and Alzheimer's disease.GeroScience · 2024Article
- The indirect relationship between sleep and cognition in the PREVENT cohort: identifying targets for intervention.Frontiers in sleep · 2023Article
- Moderating effect of cognitive reserve on brain integrity and cognitive performance.Frontiers in aging neuroscience · 2022Article
- BMRMI Reduces Depressive Rumination Possibly through Improving Abnormal FC of Dorsal ACC.Neural plasticity · 2022Article
- Midlife occupational cognitive requirements protect cognitive function in old age by increasing cognitive reserve.Frontiers in psychology · 2022Article
- PET imaging of neural activity, β-amyloid, and tau in normal brain aging.European journal of nuclear medicine and molecular imaging · 2021Review
- Verbal intelligence is a more robust cross-sectional measure of cognitive reserve than level of education in healthy older adults.Alzheimer's research & therapy · 2021Article
- Correlation Between Hippocampal Enlarged Perivascular Spaces and Cognition in Non-dementic Elderly Population.Frontiers in neurology · 2020Article
- Age-related episodic memory decline and the role of amyloid-β: a systematic review.Dementia & neuropsychologiaArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
The current study explored whether education, a proxy of cognitive reserve, modifies the association between episodic memory (EM) performance and βeta-amyloid load (Aβ), a biomarker of Alzheimer's disease, in a cohort of cognitively normal older adults. One hundred and four participants (mean age 73.3 years) evenly spread out in three bands of education were recruited. Participants underwent neuropsychological assessment, structural MRI as well as PET imaging to quantify Aβ load. Moderation analyses and the Johnson-Neyman technique were carried out to examine the interaction of education with Aβ load to predict EM performance. Linear regressions were then performed within each group of education to better illustrate the interaction effect (all analyses were controlled for age and sex). The interaction between education and Aβ load was significant (p < .05) for years of education, reaching a cutoff point of 13.5 years, above which the relationship between Aβ load and EM was no longer significant. Similarly, significant associations were found between Aβ and EM among participants with secondary (p < .01) and pre-university education (p < .01), but not with a university degree (p = .253). EM performance is associated with Aβ load in cognitively normal older individuals, and this relationship is moderated by educational attainment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.