ArticleArthritis research & therapy2019
Depression in ankylosing spondylitis and the role of disease-related and contextual factors: a cross-sectional study.
Article in Arthritis research & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Infliximab treatment reduces depressive symptoms in patients with ankylosing spondylitis: an ancillary study to a randomized controlled trial (ASSERT).Arthritis research & therapy · 2020Trial
- Disease-related and psychosocial factors associated with difficult-to-manage and treatment-refractory axial spondyloarthritis: insights from the Greek AxSpA Registry.Rheumatology international · 2026Article
- Disease activity and mental health symptoms in axial spondyloarthritis: concordant or discordant?Rheumatology (Oxford, England) · 2026Article
- A case report: Guillain-Barré syndrome probably associated with TNF inhibitor in Blau syndrome.BMC pediatrics · 2026Article
- Real-world clinical experience with upadacitinib in a cohort of Italian patients with axial spondyloarthritis.Frontiers in pharmacology · 2026Article
- Disparities in Time to Diagnosis of Radiographic Axial Spondyloarthritis.The Journal of rheumatology · 2025Observational
- A full-spectrumFrontiers in pharmacology · 2025Article
- The Mediating Effects of Self-Acceptance and Self-Evaluation on Mindfulness and Benefit -Finding in a Sample of Chinese Systemic Lupus Erythematous Patients.Patient preference and adherence · 2025Article
- Effects of depression on patients suffering from ankylosing spondylitis: a comparative study.Sao Paulo medical journal = Revista paulista de medicina · 2025Article
- Using Automated Machine Learning to Predict Necessary Upcoming Therapy Changes in Patients With Psoriasis Vulgaris and Psoriatic Arthritis and Uncover New Influences on Disease Progression: Retrospective Study.JMIR formative research · 2024Article
- Time Trend Analysis of Comorbidities in Ankylosing Spondylitis: A Population-Based Study from 53,142 Hospitalizations in Poland.Journal of clinical medicine · 2024Article
- Article
- Evaluation of the Role of Affective Temperamental Features, Automatic Thoughts, and Symptom Interpretation on Disease Activity in Patients with Axial Spondyloarthritis.Alpha psychiatry · 2023Article
- Changes in Anxiety and Depression After THA in Patients with Ankylosing Spondylitis and the Affecting Factors.Therapeutics and clinical risk management · 2023Article
- Anxiety and depression among patients with axial spondyloarthritis.European journal of rheumatology · 2022Article
- Assessment of Subclinical Psychotic Symptoms in Patients with Rheumatoid Arthritis and Spondyloarthritis.Journal of clinical medicine · 2021Article
- Gender differences in factors associated with low quality of life and depression in Korean patients with ankylosing spondylitis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Article
- Real-world experiences of the diagnosis process in Korean patients with ankylosing spondylitis based on a self-report questionnaire.The Journal of international medical research · 2021Article
- Social isolation due to the COVID-19 pandemic has led to worse outcomes in females with inflammatory arthritis.Irish journal of medical science · 2021Article
- YisaipuFrontiers in pharmacology · 2021Article
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundPatients with ankylosing spondylitis (AS) have a higher prevalence of depression compared to the general population. Comorbid depression in AS likely has a multifactorial origin. While several disease-related and contextual factors have been associated with depressive symptoms in AS, a comprehensive model of their interrelations is currently lacking. Such a model could help understand the mechanisms leading to, or maintaining, depression in AS. The objectives of the current study were to determine which factors are associated with depressive symptoms in AS and to understand their underlying relationships.
methodsData from a cross-sectional survey-based multicentre study were used. Potential determinants included both contextual and disease-related factors. Depressive symptoms were assessed by the Hospital Anxiety and Depression Subscale (HADS-D). Direct and indirect associations between risk factors and the latent depressive symptom outcome were explored using structural equation modelling. A final model was selected based on model fit criteria and clinical plausibility.
resultsAmong 245 patients, median HADS-D score was 3 (interquartile range 1-6), and 44 patients (18%) had a HADS-D score ≥ 8, indicating possible depression. In the final model, contextual factors significantly associated with depressive symptoms were male gender, being employed, lower income, lower mastery and worse satisfaction with social role participation. Bath AS Disease Activity Index (BASDAI) was the only disease-related factor that was associated with depressive symptoms, acted only indirectly via mastery, and its standardized total effect on depressive symptoms was smaller than that of several contextual factors. Mastery had a central role in the path diagram and mediated the effects of BASDAI, income and satisfaction with social role participation on depressive symptoms. The final model explained 64% of the variance in the depression outcome.
conclusionsBoth contextual and disease-related factors are associated with depressive symptoms in AS. Mastery, the extent to which one feels in control over life and disease, has a key role in this process. Results support a relevance of self-efficacy in disease management and patient education. In order to improve patients' mental health, research is warranted whether mastery and its relation with depression can be modified.
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