Evidence map›Paper›PMID 31638942›Full record

ArticleBMC neurology2019

Physio4FMD: protocol for a multicentre randomised controlled trial of specialist physiotherapy for functional motor disorder.

Glenn Nielsen, Jon Stone, Marta Buszewicz, Alan Carson, Laura H Goldstein, Kate Holt, Rachael Hunter, Jonathan Marsden, Louise Marston, Hayley Noble and 3 more

Open access · goldAbstract readClinical Trial Protocol
In one paragraph

Article in BMC neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 51 citations in OpenAlex.

  1. Trial
  2. Treatment of Functional Neurological Disorders.Journal of clinical neurology (Seoul, Korea) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Glenn NielsenMotor Control and Movement Disorders Group, Institute of Molecular and Clinical Sciences, St Georges University of London, London, UK. gnielsen@sgul.ac.uk.ORCID https://orcid.org/0000-0001-6053-5670
Jon StoneCentre for Clinical Brain Sciences, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK.ORCID https://orcid.org/0000-0001-9829-8092
Marta BuszewiczResearch Department of Primary Care and Population Health, UCL, London, UK.ORCID https://orcid.org/0000-0003-4016-5857
Alan CarsonCentre for Clinical Brain Sciences, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK.ORCID https://orcid.org/0000-0002-7425-0964
Laura H GoldsteinKing's College London, Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, UK.ORCID https://orcid.org/0000-0001-9387-3035
Kate HoltMotor Control and Movement Disorders Group, Institute of Molecular and Clinical Sciences, St Georges University of London, London, UK.
Rachael HunterResearch Department of Primary Care and Population Health, UCL, London, UK.
Jonathan MarsdenSchool of Health Professions, University of Plymouth, Plymouth, UK.
Louise MarstonResearch Department of Primary Care and Population Health, UCL, London, UK.ORCID https://orcid.org/0000-0002-9973-1131
Hayley NobleMotor Control and Movement Disorders Group, Institute of Molecular and Clinical Sciences, St Georges University of London, London, UK.ORCID https://orcid.org/0000-0002-4267-1609
Markus ReuberAcademic Neurology Unit, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK.ORCID https://orcid.org/0000-0002-4104-6705
Mark J EdwardsMotor Control and Movement Disorders Group, Institute of Molecular and Clinical Sciences, St Georges University of London, London, UK.
Physio4FMD Collaborative Group
St George's, University of London · GBEdinburgh Royal Infirmary · GBMRC Clinical Trials Unit at UCL · GBKing's College London · GB

Funding

Department of Health CDRF-2013-04-034Department of Health HTA/16/31/63Health Technology Assessment Programme 16/31/63
6 · The paper itself

Abstract

backgroundPatients with functional motor disorder (FMD) experience persistent and disabling neurological symptoms such as weakness, tremor, dystonia and disordered gait. Physiotherapy is usually considered an important part of treatment; however, sufficiently-powered controlled studies are lacking. Here we present the protocol of a randomised controlled trial (RCT) that aims to evaluate the clinical and cost effectiveness of a specialist physiotherapy programme for FMD. METHODS/

designThe trial is a pragmatic, multicentre, single blind parallel arm randomised controlled trial (RCT). 264 Adults with a clinically definite diagnosis of FMD will be recruited from neurology clinics and randomised to receive either the trial intervention (a specialist physiotherapy protocol) or treatment as usual control (referral to a community physiotherapy service suitable for people with neurological symptoms). Participants will be followed up at 6 and 12 months. The primary outcome is the Physical Function domain of the Short Form 36 questionnaire at 12 months. Secondary domains of measurement will include participant perception of change, mobility, health-related quality of life, health service utilisation, anxiety and depression. Health economic analysis will evaluate the cost impact of trial and control interventions from a health and social care perspective as well as societal perspective. DISCUSSION: This trial will be the first adequately-powered RCT of physical-based rehabilitation for FMD.

trial registrationInternational Standard Randomised Controlled Trials Number ISRCTN56136713 . Registered 27 March 2018.

Indexed as

Motor DisordersPhysical Therapy ModalitiesResearch DesignAdultHumansMaleMulticenter Studies as TopicPragmatic Clinical Trials as TopicRandomized Controlled Trials as TopicSingle-Blind MethodClinical trialConversion disorderFunctionalFunctional motor disorderPhysical therapyPhysiotherapyPsychogenicRandomised controlled trial

Identifiers

PMID31638942
PMCPMC6802344
OpenAlexW2980962023

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.