Evidence map›Paper›PMID 31638926›Full record

ReviewBMC neurology2019

A case report of disseminated nocardiosis with ocular involvement in a myasthenia gravis patient and literature review.

Shuhui Wang, Bin Jiang, Yao Li, Yanchang Shang, Zhengshan Liu, Yongbo Zhang

Open access · goldAbstract readCase ReportsReview
In one paragraph

Review in BMC neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
6.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
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  5. Review
  6. Review
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  10. EndogenousInternational medical case reports journal · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Shuhui WangDepartment of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China. drwangshuhui@163.com.ORCID http://orcid.org/0000-0002-9496-0963
Bin JiangDepartment of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
Yao LiDepartment of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
Yanchang ShangDepartment of Geriatric Neurology, Chinese People's Liberation Army General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing, 100853, China.
Zhengshan LiuDepartment of Neurology and Center for Translational Neuromedicine, University of Rochester Medical Center, New York, NY, USA.
Yongbo ZhangDepartment of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
Capital Medical University · CNChinese PLA General Hospital · CNUniversity of Rochester Medical Center · US

Funding

Research Foundation of Beijing Friendship Hospital, Capital Medical University yyqdkt2018-30
6 · The paper itself

Abstract

backgroundNocardiosis is a rare and life-threatening opportunistic infection in immunocompromised patients. Myasthenia gravis (MG) patients are potentially at risk of nocardia infection because of the use of immunosuppressive agents. To date, only 7 patients with MG have been reported to have nocardiosis. Disseminated nocardiosis with ocular involvement has not been reported in MG patients. CASE PRESENTATION: A 66-year-old man with MG who was receiving treatment with methylprednisolone and azathioprine was found to have a respiratory infection. He also had heterogeneous symptoms with skin, brain and ocular manifestations. Nocardia bacteria verified by the culture of puncture fluid, and a diagnosis of disseminated nocardiosis was made. Except for left eye blindness, the patient completely recovered from the disease with combination antibiotic therapy. To further understand nocardiosis in patients with MG, we reviewed the previous relevant literature. According to the literature, this is the first report of disseminated nocardiosis with ocular involvement in an MG patient.

conclusionsMG patients with immunosuppressant treatments are potentially at risk of a rare nocardia infection, and a favourable prognosis can be achieved through early diagnosis and appropriate antibiotic therapy.

Indexed as

Immunocompromised HostAgedAnti-Bacterial AgentsEye DiseasesHumansImmunosuppressive AgentsMaleMyasthenia GravisNocardiaNocardia InfectionsAnti-Bacterial AgentsImmunosuppressive AgentsCase reportDisseminated nocardiosisMyasthenia gravisOpportunistic infection

Identifiers

PMID31638926
PMCPMC6802327
OpenAlexW2980919854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.