Evidence map›Paper›PMID 31638765›Full record

ArticleACS chemical neuroscience2019

Azi-medetomidine: Synthesis and Characterization of a Novel α2 Adrenergic Photoaffinity Ligand.

Andrew R McKinstry-Wu, Kellie A Woll, Thomas T Joseph, Weiming Bu, E Railey White, Natarajan V Bhanu, Benjamin A Garcia, Grace Brannigan, William P Dailey, Roderic G Eckenhoff

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Classics in Chemical Neuroscience: Medetomidine.ACS chemical neuroscience · 2024
    Review
  3. The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  4. Ketamine Metabolite (2ACS chemical neuroscience · 2021
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Andrew R McKinstry-WuDepartment of Anesthesiology & Critical Care , University of Pennsylvania Perelman School of Medicine , 3620 Hamilton Walk , Philadelphia , Pennsylvania 19104 , United States.ORCID 0000-0001-7078-4603
Kellie A WollDepartment of Anesthesiology & Critical Care , University of Pennsylvania Perelman School of Medicine , 3620 Hamilton Walk , Philadelphia , Pennsylvania 19104 , United States.
Thomas T JosephDepartment of Anesthesiology & Critical Care , University of Pennsylvania Perelman School of Medicine , 3620 Hamilton Walk , Philadelphia , Pennsylvania 19104 , United States.
Weiming BuDepartment of Anesthesiology & Critical Care , University of Pennsylvania Perelman School of Medicine , 3620 Hamilton Walk , Philadelphia , Pennsylvania 19104 , United States.
E Railey WhiteDepartment of Anesthesiology & Critical Care , University of Pennsylvania Perelman School of Medicine , 3620 Hamilton Walk , Philadelphia , Pennsylvania 19104 , United States.
Natarajan V BhanuEpigenetics Institute, Department of Biochemistry and Biophysics , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.
Benjamin A GarciaEpigenetics Institute, Department of Biochemistry and Biophysics , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.
Grace BranniganCenter for Computational and Integrative Biology, Department of Physics , Rutgers University , Camden , New Jersey 08102 , United States.ORCID 0000-0001-8949-2694
William P DaileyDepartment of Chemistry , University of Pennsylvania School of Arts and Sciences , 231 S. 34th Street , Philadelphia , Pennsylvania 19104 , United States.
Roderic G EckenhoffDepartment of Anesthesiology & Critical Care , University of Pennsylvania Perelman School of Medicine , 3620 Hamilton Walk , Philadelphia , Pennsylvania 19104 , United States.
University of Pennsylvania · USRutgers, The State University of New Jersey · US

Funding

X-ray and Neutron Interferometry Studies of Anesthetic Interactions with VoltageP01GM055876 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI ECKENHOFF, RODERIC G · 1997 to 2017
$22.4M
Viral modulation of epitranscriptomic mechanismsR01AI118891 · NIAID · WASHINGTON UNIVERSITY · PI GARCIA, BENJAMIN A, WEITZMAN, MATTHEW D. · 2015 to 2025
$5.4M
Physician Postdoctoral Research Training in Perioperative Medicine (PPRTPM)T32GM112596 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Roderic G Eckenhoff, Max Kelz · 2015 to 2026
$3.4M
Understanding the Role of Combinatorial Histone PTM PatternsR01GM110174 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI GARCIA, BENJAMIN A · 2014 to 2017
$1.3M
Intersections of Sleep and Coma: Neural Pathways of Alpha-2 Adrenergic HypnosisK08GM123317 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI MCKINSTRY-WU, ANDREW RICH · 2017 to 2021
$877k
NIAID NIH HHS R01 AI118891NIGMS NIH HHS K08 GM123317NIGMS NIH HHS P01 GM055876NIGMS NIH HHS R01 GM110174NIGMS NIH HHS T32 GM112596
6 · The paper itself

Abstract

Agonists at the α

Indexed as

Adrenergic alpha-2 Receptor AgonistsAmino Acid SequenceAnimalsDose-Response Relationship, DrugHumansLigandsMedetomidinePhotoaffinity LabelsProtein Structure, SecondaryReceptors, Adrenergic, alpha-2Xenopus laevisAdrenergic alpha-2 Receptor AgonistsLigandsMedetomidinePhotoaffinity LabelsReceptors, Adrenergic, alpha-2Adrenergichypnoticmass spectrometrymolecular dynamicsphotoaffinity ligandα2

Identifiers

PMID31638765
PMCPMC6889220
OpenAlexW2982005590

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.