Evidence map›Paper›PMID 31638474›Full record

ArticleCirculation research2019

Nuclear miR-320 Mediates Diabetes-Induced Cardiac Dysfunction by Activating Transcription of Fatty Acid Metabolic Genes to Cause Lipotoxicity in the Heart.

Huaping Li, Jiahui Fan, Yanru Zhao, Xiaorong Zhang, Beibei Dai, Jiabing Zhan, Zhongwei Yin, Xiang Nie, Xiang-Dong Fu, Chen Chen and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed, 2 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 2 syntheses or guidelines pooled it, 221 citations in OpenAlex.

  1. Pooled it
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  8. Article
  9. NamiRNA-Enhancer Network: The Changing Era Challenge and Chance of miRNA.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  10. Article
  11. The heart of diabetes: unraveling metabolic drivers of cardiomyopathy.Cardiovascular diabetology. Endocrinology reports · 2025
    Review
  12. Review
  13. The roles of subcellular Argonaute 2 in cardiovascular diseases.Journal of translational internal medicine · 2025
    Article
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  15. Article
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  18. Mechanistic insight into the role of cardiac-enriched microRNAs in diabetic heart injury.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  19. Review
  20. Review

58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Huaping LiFrom the Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (H.L., J.F., Y.Z., B.D., J.Z., Z.Y., X.N., C.C., D.W.W.).
Jiahui FanFrom the Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (H.L., J.F., Y.Z., B.D., J.Z., Z.Y., X.N., C.C., D.W.W.).
Yanru ZhaoFrom the Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (H.L., J.F., Y.Z., B.D., J.Z., Z.Y., X.N., C.C., D.W.W.).
Xiaorong ZhangKey Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing (X.Z.).
Beibei DaiFrom the Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (H.L., J.F., Y.Z., B.D., J.Z., Z.Y., X.N., C.C., D.W.W.).
Jiabing ZhanFrom the Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (H.L., J.F., Y.Z., B.D., J.Z., Z.Y., X.N., C.C., D.W.W.).
Zhongwei YinFrom the Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (H.L., J.F., Y.Z., B.D., J.Z., Z.Y., X.N., C.C., D.W.W.).
Xiang NieFrom the Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (H.L., J.F., Y.Z., B.D., J.Z., Z.Y., X.N., C.C., D.W.W.).
Xiang-Dong FuDepartment of Cellular and Molecular Medicine, Institute of Genomic Medicine, University of California, La Jolla, San Diego (X.-D.F.).
Chen ChenFrom the Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (H.L., J.F., Y.Z., B.D., J.Z., Z.Y., X.N., C.C., D.W.W.).
Dao Wen WangFrom the Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (H.L., J.F., Y.Z., B.D., J.Z., Z.Y., X.N., C.C., D.W.W.).
Tongji Hospital · CNHuazhong University of Science and Technology · CNChinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleDiabetes mellitus is often associated with cardiovascular complications, which is the leading cause of morbidity and mortality among patients with diabetes mellitus, but little is known about the mechanism that connects diabetes mellitus to the development of cardiovascular dysfunction.

objectiveWe aim to elucidate the mechanism underlying hyperglycemia-induced cardiac dysfunction on a well-established db/db mouse model for diabetes mellitus and diabetic complications that lead to heart failure. METHODS AND

resultsWe first profiled the expression of microRNAs (miRNAs) by microarray and quantitative reverse transcription polymerase chain reaction on db/db mice and identified miR-320 as a key miRNA associated with the disease phenotype. We next established the clinical relevance of this finding by showing the upregulation of the same miRNA in the failing heart of patients with diabetes mellitus. We demonstrated the causal role of miR-320 in inducing diabetic cardiomyopathy, showing that miR-320 overexpression exacerbated while its inhibition improved the cardiac phenotype in db/db mice. Unexpectedly, we found that miR-320 acts as a small activating RNA in the nucleus at the level of transcription. By chromatin immunoprecipitation sequencing and chromatin immunoprecipitation quantitive polymerase chain reaction analysis of Ago2 (argonaute RISC catalytic component 2) and RNA polymerase II in response to miR-320 induction, we identified

conclusionsThese findings uncover a novel mechanism for diabetes mellitus-triggered cardiac dysfunction, provide an endogenous case for small activating RNA that has been demonstrated to date only with synthetic RNAs in transfected cells, and suggest a potential strategy to develop a miRNA-based therapy to treat diabetes mellitus-associated cardiovascular complications.

Indexed as

AnimalsCell NucleusCells, CulturedDiabetes Mellitus, ExperimentalDiabetic CardiomyopathiesFatty AcidsHumansMaleMiceMicroRNAsMyocytes, CardiacRatsTranscriptional ActivationFatty AcidsMicroRNAsMirn320 microRNA, mouseCD36 antigenscell nucleusdiabetic cardiomyopathiesfatty acidsmicroRNAs

Identifiers

PMID31638474
PMCPMC6903355
OpenAlexW2981774615

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.