Evidence map›Paper›PMID 31638219›Full record

ArticleMolecular medicine reports2019

Curcumin attenuates hypoxia/reoxygenation‑induced myocardial injury.

Wenjuan Wei, Jun Peng, Jian Li

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Wenjuan WeiDepartment of Cardiology, The First People's Hospital of Xiaoshan District, Hangzhou, Zhejiang 311200, P.R. China.
Jun PengDepartment of Cardiology, The First People's Hospital of Xiaoshan District, Hangzhou, Zhejiang 311200, P.R. China.
Jian LiDepartment of Pharmacy, Yuyao People's Hospital of Zhejiang Province, Yuyao, Zhejiang 315400, P.R. China.
The First People's Hospital of Xiaoshan District, Hangzhou · CNYuxian People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Curcumin (Cur) has been reported to function as an antioxidant and anti‑inflammatory agent and to play a role in anti‑atherosclerosis. The present study aimed to explore the protective effect of Cur on hypoxia/reoxygenation (H/R) injury. The morphological changes in H9c2 cardiomyocytes were observed under an inverted microscope. Cell viability was determined by Cell Counting Kit‑8 (CCK‑8). Lactate dehydrogenase (LDH) level, malondialdehyde (MDA) level and the antioxidant superoxide dismutase (SOD) activity were determined by corresponding kits. Apoptosis and reactive oxygen species (ROS) levels were determined by flow cytometry. Endoplasmic reticulum (ER) stress‑related factors, which were examined by quantitative real‑time polymerase chain reaction (qPCR) and western blot analysis, included 78‑kDa glucose‑regulated protein (GRP78) and C/EBP homologous protein (CHOP). Extracellular signal regulating kinase 1/2 (ERK1/2), p38, c‑Jun NH2‑terminal kinase (JNK) and the phosphorylation levels of key proteins in the mitogen‑activated protein kinase (MAPK) signaling pathway were all determined by western blot analysis. Compared to the control group, the cell morphology of the H9c2 cells was obviously altered upon H/R. Cell viability was significantly decreased, while apoptosis was significantly increased by H/R. We also observed that the levels of LDH and MDA were elevated and the activity of SOD was decreased in the H/R group. Notably, LDH, MDA and SOD levels were reversed following treatment with Cur; while apoptosis and ROS levels in the H/R injury group were decreased by Cur. H/R injury‑triggered ER stress and the MAPK signaling pathway were suppressed by Cur. These results demonstrated that Cur has a protective effect on cardiomyocytes via suppression of ER stress and the MAPK pathway.

Indexed as

AnimalsAntioxidantsApoptosisCell LineCell SurvivalCurcuminEndoplasmic Reticulum StressMAP Kinase Signaling SystemMyocardial Reperfusion InjuryMyocytes, CardiacRatsReactive Oxygen SpeciesAntioxidantsCurcuminReactive Oxygen Species

Identifiers

PMID31638219
PMCPMC6854596
OpenAlexW2981212110

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.