Evidence map›Paper›PMID 31638093›Full record

ArticleNeural regeneration research2020

Protective effect of rhodioloside and bone marrow mesenchymal stem cells infected with HIF-1-expressing adenovirus on acute spinal cord injury.

Xiao-Qin Ha, Bo Yang, Huai-Jing Hou, Xiao-Ling Cai, Wan-Yuan Xiong, Xu-Pan Wei

Open access · goldAbstract read
In one paragraph

Article in Neural regeneration research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

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  7. Mechanism of ERK/CREB pathway in pain and analgesia.Frontiers in molecular neuroscience · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Xiao-Qin HaLanzhou University Second Hospital, Lanzhou, Gansu Province, China.
Bo YangDepartment of Clinical Laboratory, Lanzhou General Hospital of Lanzhou Military Area Command; School of Clinical Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu Province, China.
Huai-Jing HouSchool of Clinical Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu Province, China.
Xiao-Ling CaiSchool of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, Gansu Province, China.
Wan-Yuan XiongSchool of Clinical Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu Province, China.
Xu-Pan WeiSchool of Clinical Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu Province, China.
Gansu University of Traditional Chinese Medicine · CNIl-Yang Pharmaceutical (South Korea) · KRLanzhou Army General Hospital · CNLanzhou University of Technology · CNLanzhou University Second Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rhodioloside has been shown to protect cells from hypoxia injury, and bone marrow mesenchymal stem cells have a good effect on tissue repair. To study the effects of rhodioloside and bone marrow mesenchymal stem cells on spinal cord injury, a rat model of spinal cord injury was established using the Infinite Horizons method. After establishing the model, the rats were randomly divided into five groups. Rats in the control group were intragastrically injected with phosphate buffered saline (PBS) (5 μL). PBS was injected at 6 equidistant points around 5 mm from the injury site and at a depth of 5 mm. Rats in the rhodioloside group were intragastrically injected with rhodioloside (5 g/kg) and intramuscularly injected with PBS. Rats in the mesenchymal stem cell (MSC) group were intramuscularly injected with PBS and intramuscularly with MSCs (8 × 10

Indexed as

acute spinal cord injuryadenovirusadenovirus gene IXbone marrow mesenchymal stem cellscombined behavioral score scaleHIF-1αnerve regenerationnerve repairRhodiola roseaSry

Identifiers

PMID31638093
PMCPMC6975151
OpenAlexW2980461960

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.