Evidence map›Paper›PMID 31638085›Full record

ReviewNeural regeneration research2020

Unfolded protein response in myelin disorders.

Wensheng Lin, Sarrabeth Stone

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neural regeneration research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Wensheng LinDepartment of Neuroscience; Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Sarrabeth StoneDepartment of Neuroscience; Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN, USA.
University of Minnesota · US

Funding

Mechanisms for maintaining ER protein homeostasis in myelinating cellsR01NS105689 · NINDS · UNIVERSITY OF MINNESOTA · PI LIN, WENSHENG · 2018 to 2022
$1.7M
The effects of NF-kB on oligodendrocytes in models of multiple sclerosisR01NS094151 · NINDS · UNIVERSITY OF MINNESOTA · PI LIN, WENSHENG · 2016 to 2020
$1.7M
NINDS NIH HHS R01 NS094151NINDS NIH HHS R01 NS105689
6 · The paper itself

Abstract

Activation of the unfolded protein response in response to endoplasmic reticulum stress preserves cell viability and function under stressful conditions. Nevertheless, persistent, unresolvable activation of the unfolded protein response can trigger apoptosis to eliminate stressed cells. Recent studies show that the unfolded protein response plays an important role in the pathogenesis of various disorders of myelin, including multiples sclerosis, Charcot-Marie-Tooth disease, Pelizaeus-Merzbacher disease, vanishing white matter disease, spinal cord injury, tuberous sclerosis complex, and hypoxia-induced perinatal white matter injury. In this review we summarize the current literature on the unfolded protein response and the evidence for its role in the pathogenesis of myelin disorders.

Indexed as

axonERmultiples sclerosismyelinoligodendrocyteSchwann cellspinal cord injuryUPR

Identifiers

PMID31638085
PMCPMC6975143
OpenAlexW2981067496

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.