Evidence map›Paper›PMID 31637970›Full record

ArticleStroke2019

Essen Risk Score in Prediction of Myocardial Infarction After Transient Ischemic Attack or Ischemic Stroke Without Prior Coronary Artery Disease.

Marion Boulanger, Linxin Li, Shane Lyons, Nicola G Lovett, Magdalena M Kubiak, Louise Silver, Emmanuel Touzé, Peter M Rothwell

Abstract read
In one paragraph

Article in Stroke, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Determinants of post-stroke cognitive impairment in patients with periodontal disease.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2025
    Trial
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  17. Impact of multimorbidity on risk and outcome of stroke: Lessons from chronic kidney disease.International journal of stroke : official journal of the International Stroke Society · 2021
    Article
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  19. Observational
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Marion BoulangerFrom the Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, United Kingdom (M.B., L.L., S.L., N.G.L., M.M.K., L.S., P.M.R.).
Linxin LiFrom the Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, United Kingdom (M.B., L.L., S.L., N.G.L., M.M.K., L.S., P.M.R.).
Shane LyonsFrom the Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, United Kingdom (M.B., L.L., S.L., N.G.L., M.M.K., L.S., P.M.R.).
Nicola G LovettFrom the Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, United Kingdom (M.B., L.L., S.L., N.G.L., M.M.K., L.S., P.M.R.).
Magdalena M KubiakFrom the Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, United Kingdom (M.B., L.L., S.L., N.G.L., M.M.K., L.S., P.M.R.).
Louise SilverFrom the Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, United Kingdom (M.B., L.L., S.L., N.G.L., M.M.K., L.S., P.M.R.).
Emmanuel TouzéNormandie Université, UNICAEN, CHU Caen Normandie, Service de Neurologie, INSERM U1237, avenue de la Côte de Nacre, Caen, France (M.B., E.T.).
Peter M RothwellFrom the Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, United Kingdom (M.B., L.L., S.L., N.G.L., M.M.K., L.S., P.M.R.).

Funding

British Heart FoundationWellcome Trust
6 · The paper itself

Abstract

Background and Purpose- More intensive secondary prevention with newer drugs may be cost-effective in patients with coronary artery disease (CAD). Whether some subgroups of patients who had a transient ischemic attack (TIA) or ischemic stroke, but no prior CAD are at similar high risk of myocardial infarction as those with prior CAD remains unclear. We determined whether the Essen score identified a subset of TIA/stroke patients without known prior CAD who, nevertheless, had a high risk of myocardial infarction on current secondary prevention management. Methods- In a population-based cohort (Oxford Vascular Study) of consecutive TIA or ischemic stroke patients recruited from 2002 to 2014, 10-year actuarial risks of myocardial infarction and of recurrent ischemic stroke were determined by face-to-face follow-up in patients with and without prior CAD using Kaplan-Meier analyses. Predictive value of the Essen score was assessed with C statistic. Results- Of 2555 patients with TIA/stroke (13 070 patient-years of follow-up), 10-year risk of myocardial infarction in those without prior CAD (n=2017, 78.9%) ranged from 0.9% (95% CI, 0-1.9) at Essen score ≤1 to 29.8% (95% CI, 7.7-46.6) in those with a score ≥5 (C statistic =0.64 [95% CI, 0.57-0.71];

Indexed as

AgedAged, 80 and overBrain IschemiaCoronary Artery DiseaseFemaleHumansIschemic Attack, TransientMaleMyocardial InfarctionRisk AssessmentRisk FactorsStrokecoronary artery diseasemyocardial infarctionrisksecondary preventiontransient ischemic attack

Identifiers

PMID31637970
PMCPMC7597993

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.