Evidence map›Paper›PMID 31637675›Full record

ArticleJournal of endocrinological investigation2020

High uric acid, reduced glomerular filtration rate and non-alcoholic fatty liver in young people with obesity.

P Di Bonito, G Valerio, M R Licenziati, E Miraglia Del Giudice, M G Baroni, A Morandi, C Maffeis, G Campana, M R Spreghini, A Di Sessa and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

P Di BonitoDepartment of Internal Medicine, "S. Maria delle Grazie" Hospital, Pozzuoli, Italy.
G ValerioDepartment of Movement Sciences and Wellbeing, University "Parthenope", Naples, Italy.
M R LicenziatiObesity and Endocrine Disease Unit, Department of Neuroscience, Santobono-Pausilipon Children's Hospital, Naples, Italy.
E Miraglia Del GiudiceDepartment of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
M G BaroniDepartment of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.
A MorandiPediatric Diabetes and Metabolic Disorders Unit, University of Verona, Verona, Italy.
C MaffeisPediatric Diabetes and Metabolic Disorders Unit, University of Verona, Verona, Italy.
G CampanaObesity and Endocrine Disease Unit, Department of Neuroscience, Santobono-Pausilipon Children's Hospital, Naples, Italy.
M R SpreghiniResearch Area for Multifactorial Disease, Children's Hospital Bambino Gesù, Via Ferdinando Baldelli 38, 00146, Rome, Italy.
A Di SessaDepartment of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
G MorinoResearch Area for Multifactorial Disease, Children's Hospital Bambino Gesù, Via Ferdinando Baldelli 38, 00146, Rome, Italy.
A CrinòResearch Area for Multifactorial Disease, Children's Hospital Bambino Gesù, Via Ferdinando Baldelli 38, 00146, Rome, Italy.
C ChiesaInstitute of Translational Pharmacology, National Research Council, Rome, Italy.
L PacificoPoliclinico Umberto I Hospital, "Sapienza" University of Rome, Rome, Italy.
M MancoResearch Area for Multifactorial Disease, Children's Hospital Bambino Gesù, Via Ferdinando Baldelli 38, 00146, Rome, Italy. melania.manco@opbg.net.
Bambino Gesù Children's Hospital · ITSantobono Children's Hospital · ITSapienza University of Rome · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Verona · ITIstituto di Farmacologia Traslazionale · ITParthenope University of Naples · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the association between high uric acid (UA), reduced estimated glomerular filtration rate (eGFR), and non-alcoholic fatty liver disease (NAFLD) in outpatient children and adolescents with overweight (OW) or obesity (OB).

methodsAnthropometric, biochemical, hepatic ultrasound and eGFR data were available from 2565 young people with OW/OB (age 5-18 years). eGFR was calculated using the Schwartz's bedside formula and reduced eGFR (ReGFR

resultsThe population was stratified in four categories: (1) normal eGFR and absence of NAFLD (ReGFR

conclusionsHigh levels of UA were independently associated with ReGFR, NAFLD and the combination of both conditions in young people with OW/OB. The strength of this association was the highest in cases presenting both reduced eGFR and NAFLD. UA may serve as marker to identify patients at risk for these conditions.

Indexed as

ChildFemaleGlomerular Filtration RateHumansLiverMaleNon-alcoholic Fatty Liver DiseaseObesityRenal Insufficiency, ChronicUltrasonographyUric AcidUric AcidChronic kidney diseaseFatty liverUric acid

Identifiers

PMID31637675
OpenAlexW2982044319

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.