ArticleThe journal of physiological sciences : JPS2019
The effects of moderate exercise and overtraining on learning and memory, hippocampal inflammatory cytokine levels, and brain oxidative stress markers in rats.
Article in The journal of physiological sciences : JPS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of acute, subacute, and chronic exercise on plasma s-Klotho levels: a systematic review and meta-analysis.Journal of physiology and biochemistry · 2026Pooled it
- Mapping the effects of exercise on cognition and physical function: a scoping review of rodent studies.Frontiers in physiology · 2026Pooled it
- The Impact of Overtraining on Anxiety-Like Behavior and Tight Junction Proteins of the Blood-Brain Barrier in Mice.Brain and behavior · 2026Article
- Divergent associations of estimated cardiorespiratory fitness with cognitive trajectories in Chinese and U.S. middle-aged and older adults: A descriptive cross-national comparison from CHARLS and HRS.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Observational
- Review
- Myokine Cathepsin B as a Key Muscle-Brain Axis Regulator Mediates Treadmill-Running-Induced Hippocampal Neurogenesis and Cognitive Improvement in Mice.Research (Washington, D.C.) · 2026Article
- Article
- High-Intensity Interval Training Improves Memory Deficits in Obese Mice by Enhancing Osteocalcin-Driven Astrocytic BDNF Expression and Stimulating Hippocampal Neurogenesis.Neurochemical research · 2025Article
- Battle of the Biomarkers of Systemic Inflammation.Biology · 2025Review
- Association between physical activity level and cardiovascular disease: An empirical analysis based on CHARLS data in 2018.PloS one · 2025Article
- The influence of vibratory massage after physical exertion on selected psychological processes.Frontiers in psychology · 2024Article
- Effects of Simulated Equestrian Therapy in Improving Motor Proficiency among Down Syndrome Children - A Randomized Controlled Trial.International journal of exercise science · 2024Article
- The Interaction Effect of Sleep Deprivation and Treadmill Exercise in Various Durations on Spatial Memory with Respect to the Oxidative Status of Rats.Neurochemical research · 2023Article
- Effects of Treadmill Exercise on Social Behavior in Rats Exposed to Thimerosal with Respect to the Hippocampal Level of GluN1, GluN2A, and GluN2B.Journal of molecular neuroscience : MN · 2022Article
- Complicated Role of Exercise in Modulating Memory: A Discussion of the Mechanisms Involved.Neurochemical research · 2022Review
- The Muscle-Brain Axis and Neurodegenerative Diseases: The Key Role of Mitochondria in Exercise-Induced Neuroprotection.International journal of molecular sciences · 2021Review
- Reproductive Toxicity ofJournal of human reproductive sciencesArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the exercise intensity effects on rats' memory and learning, animals were divided into control, moderate training (MT), and overtraining (OT) groups. At training last week, learning and memory was assessed using Morris water maze (MWM) and passive avoidance (PA) tests. Finally, the rat's brains were removed for evaluating oxidative stress and inflammatory cytokines. Overtraining impaired animal's performance in MWM and PA tests. In MT group, hippocampal levels of interleukin 1 beta (IL-1β) and malondialdehyde (MDA) increased, and thiol contents in hippocampal and cortical tissues decreased compared to control. In OT group, tumor necrosis factor α, IL-1β, and C-reactive protein hippocampal levels increased, MDA and nitric oxide metabolite in hippocampal and cortical tissues increased, thiol contents, catalase and superoxide dismutase activity in hippocampal and cortical tissues decreased compared to control and MT groups. Overtraining might lead to learning and memory impairment by increasing the inflammatory cytokine and oxidative stress markers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.