Evidence map›Paper›PMID 31637568›Full record

ReviewHeart failure reviews2020

Neurohormones, inflammatory mediators, and cardiovascular injury in the setting of heart failure.

Liza Grosman-Rimon, Filio Billia, Evan Wright, Shemy Carasso, Gabby Elbaz-Greener, Erez Kachel, Vivek Rao, David Cherney

Abstract readReview
PubMed Publisher
In one paragraph

Review in Heart failure reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Understanding the Mortality Trends in Patients With Ventricular Arrhythmias and Cardiomyopathy: A 25-Year Retrospective Analysis From 1999-2024.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026
    Observational
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Neurohumoral Activation in Heart Failure.International journal of molecular sciences · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Establishment of a lncRNA-miRNA-mRNA network in a rat model of atrial fibrosis by whole transcriptome sequencing.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2022
    Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Liza Grosman-RimonDivision of Cardiovascular Surgery, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, ON, M5S, Canada.ORCID http://orcid.org/0000-0003-1456-6083
Filio BilliaDivision of Cardiology, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, ON, M5S, Canada.
Evan WrightTechnion American Medical School, The Ruth and Bruce Rappaport Faculty of Medicine, St. Bat Galim,, Haifa, Israel.
Shemy CarassoCardiovascular Department and Research Center of Baruch Padeh Medical Center, Poriya, NY, 10010, USA.
Gabby Elbaz-GreenerCardiovascular Department and Research Center of Baruch Padeh Medical Center, Poriya, NY, 10010, USA.
Erez KachelCardiovascular Department and Research Center of Baruch Padeh Medical Center, Poriya, NY, 10010, USA.
Vivek RaoDivision of Cardiovascular Surgery, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, ON, M5S, Canada.
David CherneyDivision of Nephrology, University Health Network, University of Toronto, Toronto, ON, M5S, Canada. David.cherney@uhn.ca.
University Health Network · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurohormones and inflammatory mediators have effects in both the heart and the peripheral vasculature. In patients with heart failure (HF), neurohormonal activation and increased levels of inflammatory mediators promote ventricular remodeling and development of HF, as well as vascular dysfunction and arterial stiffness. These processes may lead to a vicious cycle, whereby arterial stiffness perpetuates further ventricular remodeling leading to exacerbation of symptoms. Although significant advances have been made in the treatment of HF, currently available treatment strategies slow, but do not halt, this cycle. The current treatment for HF patients involves the inhibition of neurohormonal activation, which can reduce morbidity and mortality related to this condition. Beyond benefits associated with neurohormonal blockade, other strategies have focused on inhibition of inflammatory pathways implicated in the pathogenesis of HF. Unfortunately, attempts to target inflammation have not yet been successful to improve prognosis of HF. Further work is required to interrupt key maladaptive mechanisms involved in disease progression.

Indexed as

Heart FailureHumansInflammation MediatorsNeurotransmitter AgentsVentricular RemodelingInflammation MediatorsNeurotransmitter AgentsArterial stiffnessInflammatory mediators and cardiovascular injury in the setting of heart failureNeurohormonesVascular dysfunctionVentricular remodeling

Identifiers

PMID31637568
OpenAlexW2982133945

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.