Evidence map›Paper›PMID 31637440›Full record

ArticleThe Journal of clinical endocrinology and metabolism2020

Hippocampal Neurochemical Profile and Glucose Transport Kinetics in Patients With Type 1 Diabetes.

Petr Bednařík, Pierre-Gilles Henry, Amir Khowaja, Nathan Rubin, Anjali Kumar, Dinesh Deelchand, Lynn E Eberly, Elizabeth Seaquist, Gülin Öz, Amir Moheet

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Journal of neurotrauma · 2021
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Petr BednaříkCenter for Magnetic Reson ance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota.
Pierre-Gilles HenryCenter for Magnetic Reson ance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota.
Amir KhowajaDivision of Diabetes, Endocrinology and Metabolism, Department of Medicine, University of Minnesota, Minneapolis, Minnesota.
Nathan RubinDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota.
Anjali KumarDivision of Diabetes, Endocrinology and Metabolism, Department of Medicine, University of Minnesota, Minneapolis, Minnesota.
Dinesh DeelchandCenter for Magnetic Reson ance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota.
Lynn E EberlyDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota.
Elizabeth SeaquistDivision of Diabetes, Endocrinology and Metabolism, Department of Medicine, University of Minnesota, Minneapolis, Minnesota.
Gülin ÖzCenter for Magnetic Reson ance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota.
Amir MoheetDivision of Diabetes, Endocrinology and Metabolism, Department of Medicine, University of Minnesota, Minneapolis, Minnesota.

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
TRD4 - Ultrahigh Field Engineering and SafetyP41EB027061 · NIBIB · UNIVERSITY OF MINNESOTA · PI Gregory John Metzger, KAMIL UGURBIL · 2019 to 2026
$11.7M
NMR Imaging and SpectroscopyP41EB015894 · NIBIB · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2017
$8.4M
Measurement of glucose homestatsis in human brain by NMRR01NS035192 · NINDS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI OZ, GULIN, SEAQUIST, ELIZABETH R. · 1997 to 2022
$8.3M
Institutional Career Development CoreKL2TR002492 · NCATS · UNIVERSITY OF MINNESOTA · PI INGBAR, DAVID H · 2018 to 2022
$6.3M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)KL2TR000113 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$5.4M
TRAINING GRANT IN DIABETES, ENDOCRINOLOGY, &METABOLISMT32DK007203 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LISA Senye CHOW, Douglas G Mashek · 1986 to 2026
$4.3M
Institutional Center Cores for Advanced NeuroimagingP30NS076408 · NINDS · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2020
$4.2M
High Performance Connectome Upgrade for Human 3T MR ScannerS10OD017974 · OD · UNIVERSITY OF MINNESOTA · PI LIM, KELVIN O. · 2014 to 2014
$600k
NCATS NIH HHS KL2 TR000113NCATS NIH HHS KL2 TR002492NCATS NIH HHS UL1 TR002494NIBIB NIH HHS P41 EB015894NIBIB NIH HHS P41 EB027061NIDDK NIH HHS T32 DK007203NIH HHS S10 OD017974NINDS NIH HHS P30 NS076408NINDS NIH HHS R01 NS035192
6 · The paper itself

Abstract

contextLongstanding type 1 diabetes (T1D) may lead to alterations in hippocampal neurochemical profile. Upregulation of hippocampal glucose transport as a result of recurrent exposure to hypoglycemia may preserve cognitive function during future hypoglycemia in subjects with T1D and impaired awareness of hypoglycemia (IAH). The effect of T1D on hippocampal neurochemical profile and glucose transport is unknown.

objectiveTo test the hypothesis that hippocampal neurochemical composition is altered in T1D and glucose transport is upregulated in T1D with IAH. DESIGN AND

participantsHippocampal neurochemical profile was measured with single-voxel magnetic resonance spectroscopy at 3T during euglycemia in 18 healthy controls (HC), 10 T1D with IAH, and 12 T1D with normal awareness to hypoglycemia (NAH). Additionally, 12 HC, 8 T1D-IAH, and 6 T1D-NAH were scanned during hyperglycemia to assess hippocampal glucose transport with metabolic modeling.

settingUniversity medical center.

main outcome measuresConcentrations of hippocampal neurochemicals measured during euglycemia and ratios of maximal transport rate to cerebral metabolic rate of glucose (Tmax/CMRGlc), derived from magnetic resonance spectroscopy-measured hippocampal glucose as a function of plasma glucose.

resultsComparison of hippocampal neurochemical profile revealed no group differences (HC, T1D, T1D-IAH, and T1D-NAH). The ratio Tmax/CMRGlc was not significantly different between the groups, T1D-IAH (1.58 ± 0.09) and HC (1.65 ± 0.07, P = 0.54), between T1D-NAH (1.50 ± 0.09) and HC (P = 0.19), and between T1D-IAH and T1D-NAH (P = 0.53).

conclusionsSubjects with T1D with sufficient exposure to recurrent hypoglycemia to create IAH did not have alteration of Tmax/CMRglc or neurochemical profile compared with participants with T1D-NAH or HC.

Indexed as

AdultDiabetes Mellitus, Type 1FemaleGlucoseGlucose Clamp TechniqueHippocampusHumansHyperglycemiaHypoglycemiaKineticsMagnetic Resonance SpectroscopyMaleMiddle AgedUp-RegulationGlucose

Identifiers

PMID31637440
PMCPMC7046023

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.