Evidence map›Paper›PMID 31637432›Full record

ArticleThe Journal of infectious diseases2020

Developing Broad-Spectrum Antivirals Using Porcine and Rhesus Macaque Models.

Xueer Qiu, Justin Taft, Dusan Bogunovic

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Xueer QiuDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Justin TaftDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Dusan BogunovicDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Icahn School of Medicine at Mount Sinai · USChild Health and Development Institute · US

Funding

Human ISG15 and USP18 Deficiencies Underlying Type I InterferonopathiesR01AI127372 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Dusan Bogunovic · 2017 to 2026
$4.7M
ZIKA VIRUS RESISTANCE; HOST DETERMINANTSR21AI129827 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BOGUNOVIC, DUSAN · 2017 to 2018
$466k
Interplay between Negative Regulators of Type I Interferon and HIV controlR21AI134366 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BOGUNOVIC, DUSAN, SIMON, VIVIANA A · 2017 to 2018
$466k
NIAID NIH HHS R01 AI127372NIAID NIH HHS R21 AI129827NIAID NIH HHS R21 AI134366
6 · The paper itself

Abstract

ISG15-deficient humans exhibit permanent, low-level expression of antiviral effectors that safely protect them from various viruses. Because the murine ISG15 axis functions differently, we identified animal models that recapitulate the human condition for the development of ISG15-targeting broad-spectrum antivirals. Canine, porcine, and rhesus macaque ISG15, such as human ISG15, stabilize USP18, a potent inhibitor of type I interferon (IFN)-I. Type I Interferon-primed ISG15-knockout porcine and rhesus cells demonstrate enhanced ISG expression and protection against vesicular stomatitis Indiana virus infection compared with wild type. Collectively, we unveil the interspecies diversity of the ability of ISG15/USP18 axis to control IFN-I signaling and reveal the therapeutic potential of ISG15-deficient porcine and rhesus models.

Indexed as

AnimalsAntiviral AgentsCells, CulturedCytokinesGene DeletionGene Expression Regulation, EnzymologicHumansMacaca mulattaPhylogenySpecies SpecificitySwineUbiquitinsUbiquitin ThiolesteraseAntiviral AgentsCytokinesUbiquitinsUbiquitin Thiolesterasebroad-spectrum antiviralISG15 deficiencyUSP18

Identifiers

PMID31637432
PMCPMC7050986
OpenAlexW2981386938

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.