SynthesisThe Journal of frailty & aging2019
The Relationship between Physical Frailty and Mild Cognitive Impairment in the Elderly: A Systematic Review.
Synthesis in The Journal of frailty & aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Deprescribing preventive medications in older adults with advanced frailty, dementia, or limited life expectancy: a systematic review and meta-analysis.BMC geriatrics · 2026Pooled it
- Association of malnutrition with cognitive frailty in China: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- Frailty and cognitive impairment in Parkinson's disease: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Pooled it
- Cognitive impairment in people with physical frailty using the phenotype model: A systematic review and meta analysis.International journal of geriatric psychiatry · 2022Pooled it
- Sensory and motor correlates of frailty: dissociation between frailty phenotype and frailty index.BMC geriatrics · 2022Trial
- Prospective Associations between Plasma Amyloid-Beta 42/40 and Frailty in Community-Dwelling Older Adults.The journal of prevention of Alzheimer's disease · 2021Trial
- Trial
- Cognitive frailty and adverse outcomes in older people with maintenance hemodialysis: a multicenter prospective cohort study.BMC geriatrics · 2026Article
- Prevalence and Associated Factors of Frailty in Middle-Aged and Elderly Patients with Atrial Fibrillation: An Exploratory Machine Learning Analysis.Clinical interventions in aging · 2026Article
- Association of a novel nutritional index, the triglyceride-cholesterol-body weight index (TCBI), with incident mild cognitive impairment: CHARLS 2011-2018.Frontiers in nutrition · 2026Article
- Linking Motor and Cognitive Decline in Aging: Gait Variability and Working Memory as Early Markers of Frailty.Healthcare (Basel, Switzerland) · 2025Article
- Physical frailty and MRI markers of structural brain integrity in the community-dwelling late middle-aged and old adults.Scientific reports · 2025Article
- Cognitive frailty: a useful concept or a source of confusion? Insights from a survey of European geriatricians.BMC geriatrics · 2025Article
- Frailty in motion: Amnestic mild cognitive impairment and Alzheimer's disease cohorts display heterogeneity in multimorbidity classification and longitudinal transitions.Journal of Alzheimer's disease : JAD · 2025Article
- Relationships between physical frailty and cognitive decline over 8 years: A longitudinal study among community-dwelling older Chinese immigrants.The journal of nutrition, health & aging · 2025Article
- Development and validation of a frailty risk model for patients with mild cognitive impairment.Scientific reports · 2025Article
- Associations between frailty and cognitive impairment in Parkinson´s disease: a cross-sectional study.Aging clinical and experimental research · 2025Observational
- Prevalence and related factors of physical function and cognitive impairment among older adults: a population-based regional cross-sectional study.Frontiers in aging neuroscience · 2025Article
- Association of cognitive function with frailty, nutritional status, and quality of life in older adults with mild cognitive impairment.PloS one · 2025Article
- Comparative study of insulin resistance surrogate indices to predict mild cognitive impairment among Chinese non-diabetic adults.Lipids in health and disease · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPhysical frailty (PF) appears to be associated with low cognitive performance and mild cognitive impairment (MCI). This review evaluated and synthesized the evidence of studies investigating the association between PF and MCI, the prevalence of both conditions and the rate of conversion of healthy older adult to one of them during the follow-up.
methodsA systematic review was performed according to the PRISMA recommendations in the Pubmed, SciELO and LILACS databases. Five studies were eligible according to inclusion and exclusion criteria.
resultsRegarding the study design, cross-sectional studies prevailed. Most studies showed a positive association between PF and MCI. Moreover, PF seems to predict a worse cognitive trajectory among participants with MCI and it is associated to a higher risk of developing MCI.
conclusionOur findings suggest a significant association between PF and MCI. Further longitudinal studies are needed to better explore causality.
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