ArticleThe Journal of frailty & aging2019
Relationship of Physical Frailty to Phosphocreatine Recovery in Muscle after Mild Exercise Stress in the Oldest-Old Women.
Article in The Journal of frailty & aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Acid-Base Dysregulation Links Aging Metabolism to Frailty.Aging cell · 2026Article
- Creatine monohydrate supplementation for older adults and clinical populations.Journal of the International Society of Sports Nutrition · 2025Review
- Characterization of Dynamic Adaptation to Stressors Using Multisystem Stimulus-Response Data: The Study of Physical Resilience in Aging Pilot.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Metabolic dysfunction and the development of physical frailty: an aging war of attrition.GeroScience · 2024Review
- Effect of prehabilitation exercises on postoperative frailty in patients undergoing laparoscopic colorectal cancer surgery.Frontiers in oncology · 2024Article
- Nonlinear modeling of oral glucose tolerance test response to evaluate associations with aging outcomes.PloS one · 2024Article
- Physiological Systems in Promoting Frailty.Comprehensive Physiology · 2022Review
- One-Dimensional Statistical Parametric Mapping Identifies Impaired Orthostatic Cerebrovascular and Cardiovascular Response in Frailty Index.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- The physical frailty syndrome as a transition from homeostatic symphony to cacophony.Nature aging · 2021Article
- The Current State of HIV and Aging: Findings Presented at the 10th International Workshop on HIV and Aging.AIDS research and human retroviruses · 2020Article
- Dynamics and interactions of cobalamin and folate status during advanced aging - a longitudinal study in a community-dwelling cohort with multiple follow-ups.Nutrition journal · 2020Article
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Authors and funding
9 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhysical frailty is a clinical syndrome associated with aging and manifesting as slowness, weakness, reduced physical activity, weight loss, and/or exhaustion. Frail older adults often report that their major problem is "low energy", and there is indirect evidence to support the hypothesis that frailty is a syndrome of dysregulated energetics. We hypothesized that altered cellular energy production underlies compromised response to stressors in the frail.
methodsWe conducted a pilot study to assess muscle energetics in response to a mild isometric exercise challenge in women (n=30) ages 84-93 years. The frailty status was assessed by a validated physical frailty instrument. Localized phosphorus (P31) magnetic resonance spectroscopy with a 1.5T magnet was used to assess the kinetics of Phosphocreatine recovery in the tibialis anterior muscle following maximal isometric contraction for 30 seconds.
resultsPhosphocreatine recovery following exertion, age-adjusted, was slowest in the frail group (mean=189 sec; 95%CI: 150,228) compared to pre-frail (mean=152 sec; 95%CI: 107,197) and nonfrail subjects (mean=132 sec; 95%CI: 40,224). The pre-frail and frail groups had 20 sec (95%CI: -49,89) and 57 sec (95%CI: -31,147) slower phosphocreatine recovery, respectively, than the non-frail. This response was paralleled by dysregulation in glucose recovery in response to oral glucose tolerance test in women from the same study population.
conclusionsImpaired muscle energetics and energy metabolism might be implicated in the physical frailty syndrome.
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