Evidence map›Paper›PMID 31637346›Full record

ArticleJournal of the Endocrine Society2019

Nonalcoholic Fatty Liver Disease in Nonobese Subjects of African Origin Has Atypical Metabolic Characteristics.

Debbie S Thompson, Ingrid A Tennant, Deanne P Soares, Clive Osmond, Chris D Byrne, Terrence E Forrester, Michael S Boyne

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Debbie S ThompsonCaribbean Institute for Health Research, The University of the West Indies, Kingston, Jamaica.ORCID 0000-0001-6781-7646
Ingrid A TennantCaribbean Institute for Health Research, The University of the West Indies, Kingston, Jamaica.
Deanne P SoaresDepartment of, Surgery, Radiology, Anesthesia and Intensive Care, The University of the West Indies, Kingston, Jamaica.ORCID 0000-0002-6458-8240
Clive OsmondMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom.ORCID 0000-0002-9054-4655
Chris D ByrneNutrition and Metabolism, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.ORCID 0000-0002-9602-8694
Terrence E ForresterCaribbean Institute for Health Research, The University of the West Indies, Kingston, Jamaica.ORCID 0000-0001-7976-8669
Michael S BoyneCaribbean Institute for Health Research, The University of the West Indies, Kingston, Jamaica.ORCID 0000-0003-4560-9285
University of the West Indies · JMMRC Lifecourse Epidemiology Unit · GBSouthampton General Hospital · GB

Funding

Medical Research Council MC_UP_A620_1016Medical Research Council MC_UU_12011/3
6 · The paper itself

Abstract

backgroundNonobese nonalcoholic fatty liver disease is reported in several populations. However, because persons of African origin display unique fat accumulation, insulin resistance, and lipid profiles, we investigated fatty liver in nonobese persons of African origin.

methodWe recruited 78 urban Jamaican volunteers. CT was used to estimate liver and abdominal fat and dual-energy X-ray absorptiometry to measure body composition. Fasting blood was collected for lipids, alanine aminotransferase (ALT), adiponectin, and fetuin-A. Homeostatic model assessment of insulin resistance (HOMA-IR), whole-body insulin sensitivity index (WBISI), insulinogenic index (IGI), and oral disposition index (oDI) were calculated after a 75-g oral glucose tolerance test.

resultsFifty-two percent of participants were male; mean (±SD) age was 28.5 ± 7.8 years, and body mass index was 22.4 ± 3.0 kg/m

conclusionsIn nonobese Afro-Caribbean participants, greater liver fat was associated with weight and height and lower fasting insulin and hyperinsulinemia appears to be influential in the reduction of NAFLD. These findings may be influenced by ethnicity, body size, and method of estimating liver fat.

Indexed as

adiponectinfetuin-Ainsulin resistancenonobese nonalcoholic fatty liver disease

Identifiers

PMID31637346
PMCPMC6795019
OpenAlexW2969899072

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.